LDC1267

• 常用名: LDC1267
• 英文名: LDC1267
• CAS号: 1361030-48-9
• 分子量: 560.548
• 密度: 1.3±0.1 g/cm3
• 沸点: 628.4±55.0 °C at 760 mmHg
• 分子式: C₃₀H₂₆F₂N₄O₅
• 熔点: N/A
• 闪点: 333.8±31.5 °C

LDC1267用途

LDC1267是TAM(Tyro3,Axl和Mer)激酶高效选择性抑制剂,对Tyro3/Axl/Mer IC50值分别为<5 nM/8 nM/29 nM。

LDC1267名称

• 中文名: N-[4-[(6,7-二甲氧基-4-喹啉基)氧基]-3-氟苯基]-4-乙氧基-1-(4-氟-2-甲基苯基)-1H-吡唑-3-甲酰胺
• 英文名: N-[4-[(6,7-dimethoxy-4-quinolyl)oxy]-3-fluoro-phenyl]-4-ethoxy-1-(4-fluoro-2-methyl-phenyl)pyrazole-3-carboxamide

LDC1267生物活性

• 描述: LDC1267是TAM(Tyro3,Axl和Mer)激酶高效选择性抑制剂,对Tyro3/Axl/Mer IC50值分别为<5 nM/8 nM/29 nM。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> TAM Receptor
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Paolino M, et al. The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature. 2014 Mar 27;507(7493):508-12.

LDC1267物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 628.4±55.0 °C at 760 mmHg
• 分子式: C₃₀H₂₆F₂N₄O₅
• 分子量: 560.548
• 闪点: 333.8±31.5 °C
• 精确质量: 560.187134
• PSA: 96.73000
• LogP: 6.48
• InChIKey: ISPBCAXOSOLFME-UHFFFAOYSA-N
• SMILES: CCOc1cn(-c2ccc(F)cc2C)nc1C(=O)Nc1ccc(Oc2ccnc3cc(OC)c(OC)cc23)c(F)c1
• 外观性状: 粉末
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.610
• 储存条件: -20℃

LDC1267靶点实验

查看更多实验

实验名称：Inhibition of CDC2L1 (unknown origin) assessed as remaining activity at 1 uM by KINOM... 来源：ChEMBL 靶标：Cyclin-dependent kinase 11B External Id：CHEMBL5649378

实验名称：Inhibition of CLK1 (unknown origin) assessed as remaining activity at 1 uM by KINOMEs... 来源：ChEMBL 靶标：Dual specificity protein kinase CLK1 External Id：CHEMBL5649379

实验名称：Inhibition of FGFR2 (unknown origin) assessed as remaining activity at 1 uM by KINOME... 来源：ChEMBL 靶标：Fibroblast growth factor receptor 2 External Id：CHEMBL5649380

实验名称：Inhibition of MKNK1 (unknown origin) assessed as remaining activity at 1 uM by KINOME... 来源：ChEMBL 靶标：MAP kinase-interacting serine/threonine-protein kinase 1 External Id：CHEMBL5649381

实验名称：Inhibition of MLK3 (unknown origin) assessed as remaining activity at 1 uM by KINOMEs... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5649382

实验名称：Inhibition of TBK1 (unknown origin) assessed as remaining activity at 1 uM by KINOMEs... 来源：ChEMBL 靶标：Serine/threonine-protein kinase TBK1 External Id：CHEMBL5649383

实验名称：Inhibition of BIKE (unknown origin) assessed as remaining activity at 1 uM by KINOMEs... 来源：ChEMBL 靶标：BMP-2-inducible protein kinase External Id：CHEMBL5649384

实验名称：Inhibition of EPHB3 (unknown origin) assessed as remaining activity at 1 uM by KINOME... 来源：ChEMBL 靶标：Ephrin type-B receptor 3 External Id：CHEMBL5649385

实验名称：Inhibition of JNK1 (unknown origin) assessed as remaining activity at 1 uM by KINOMEs... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 8 External Id：CHEMBL5649386

实验名称：Inhibition of PIK3CA E542K mutant (unknown origin) assessed as remaining activity at ... 来源：ChEMBL 靶标：Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform External Id：CHEMBL5649387

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LDC1267英文别名

• N-{4-[(6,7-Dimethoxy-4-quinolinyl)oxy]-3-fluorophenyl}-4-ethoxy-1-(4-fluoro-2-methylphenyl)-1H-pyrazole-3-carboxamide
• LDC1267