XD14

• 常用名: XD14
• 英文名: XD14
• CAS号: 1370888-71-3
• 分子量: 421.510
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₀H₂₇N₃O₅S
• 熔点: N/A
• 闪点: N/A

XD14用途

XD14是BET溴结构域抑制剂,BRD4(1),BRD2(1),BRD3(1),BRD3(2),BRD2(2)和BRD4的Kd值分别为160,170,380,490,830和850 nM。(2)分别。

XD14名称

• 英文名: XD14

XD14生物活性

• 描述: XD14是BET溴结构域抑制剂,BRD4(1),BRD2(1),BRD3(1),BRD3(2),BRD2(2)和BRD4的Kd值分别为160,170,380,490,830和850 nM。(2)分别。
• 体外研究: BET溴结构域抑制剂,BRD4(1),BRD2(1),BRD3(1),BRD3(2),BRD2(2)和BRD4(2)的Kd值分别为160,170,380,490,830和850 nM。)。XD14还抑制BRDT(1),CBP,p300和BRDT(2),Kd值分别为1.2,1.6,2.6和3.7μM。

XD14物理化学性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₂₀H₂₇N₃O₅S
• 分子量: 421.510
• 精确质量: 421.167145
• LogP: 2.38
• InChIKey: DPBKLIVPNYGQQG-UHFFFAOYSA-N
• SMILES: CCc1c(C(=O)Nc2cc(S(=O)(=O)N(CC)CC)ccc2O)[nH]c(C)c1C(C)=O
• 折射率: 1.592
• 储存条件: -20°C

XD14靶点实验

查看更多实验

实验名称：Binding affinity to human BRD2 domain 1 assessed as dissociation constant by isotherm... 来源：ChEMBL 靶标：Bromodomain-containing protein 2 External Id：CHEMBL5056846

实验名称：Binding affinity to human BRD2 domain 2 assessed as dissociation constant by isotherm... 来源：ChEMBL 靶标：Bromodomain-containing protein 2 External Id：CHEMBL5056845

实验名称：Binding affinity to human BRD3 domain 1 assessed as dissociation constant by isotherm... 来源：ChEMBL 靶标：Bromodomain-containing protein 3 External Id：CHEMBL5056844

实验名称：Binding affinity to human BRD4 domain 1 (unknown origin) assessed as dissociation con... 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL5056850

实验名称：Cytotoxicity against human MOLT-4 cells assessed as cell viability at 5 uM by CellTit... 来源：ChEMBL 靶标：MOLT-4 External Id：CHEMBL5056849

实验名称：Experimentally measured binding affinity data (Kd) for protein-ligand complexes deriv... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-Kd for protein-ligand complexes

实验名称：Cytotoxicity against human TALL-1 cells assessed as cell viability at 5 uM by CellTit... 来源：ChEMBL 靶标：TALL-1 External Id：CHEMBL5056848

实验名称：Growth inhibition of human HL60 cells at 10 uM after 48 hrs by sulforhodamine B assay 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL4368989

实验名称：Cytotoxicity against human HL-60 cells assessed as cell viability at 5 uM by CellTite... 来源：ChEMBL 靶标：HL-60 External Id：CHEMBL5056847

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

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XD14英文别名

• XD14
• 4-Acetyl-N-[5-(diethylsulfamoyl)-2-hydroxyphenyl]-3-ethyl-5-methyl-1H-pyrrole-2-carboxamide
• MFCD23144071