(6aR,10aR)-1-羟基-6,6-二甲基-3-(2-甲基辛-2-基)-6a,7,10,10a-四氢苯并[c]色原烯-9-羧酸

• 常用名: (6aR,10aR)-1-羟基-6,6-二甲基-3-(2-甲基辛-2-基)-6a,7,10,10a-四氢苯并[c]色原烯-9-羧酸
• 英文名: Lenabasum
• CAS号: 137945-48-3
• 分子量: 400.55100
• 密度: 1.085g/cm3
• 沸点: 495.7ºC at 760mmHg
• 分子式: C₂₅H₃₆O₄
• 熔点: N/A
• 闪点: 158.5ºC

用途

A synthetic nonpsychoactive cannabinoid acid with potent analgesic and anti-inflammatory activity in vivo, binds directly and selectively to PPARγ.

名称

• 中文名: (6aR,10aR)-1-羟基-6,6-二甲基-3-(2-甲基辛-2-基)-6a,7,10,10a-四氢苯并[c]色原烯-9-羧酸
• 英文名: (6aR,10aR)-1-hydroxy-6,6-dimethyl-3-(2-methyloctan-2-yl)-6a,7,10,10a-tetrahydrobenzo[c]chromene-9-carboxylic acid

物理化学性质

• 密度: 1.085g/cm3
• 沸点: 495.7ºC at 760mmHg
• 分子式: C₂₅H₃₆O₄
• 分子量: 400.55100
• 闪点: 158.5ºC
• 精确质量: 400.26100
• PSA: 66.76000
• LogP: 6.31580
• InChIKey: YCHYFHOSGQABSW-RTBURBONSA-N
• SMILES: CCCCCCC(C)(C)c1cc(O)c2c(c1)OC(C)(C)C1CC=C(C(=O)O)CC21
• 蒸汽压: 1.2E-10mmHg at 25°C
• 折射率: 1.535

靶点实验

查看更多实验

实验名称：Ratio of drug uptake in brain to plasma of Sprague-Dawley rat at 1 mg/kg, sc 来源：ChEMBL 靶标：Nucleic Acid External Id：CHEMBL1952696

实验名称：Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4651404

实验名称：Human CB1 receptor (Cannabinoid receptors) 来源：IUPHAR-DB 靶标：CB1 receptor (Cannabinoid receptors) [Homo sapiens] External Id：56_Human

实验名称：Antinociceptive activity in CD1 mouse assessed as increase in paw withdrawal latency ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3293676

实验名称：Drug metabolism in cynomolgus monkey hepatocytes assessed as parent compound remainin... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3269557

实验名称：Drug metabolism in dog hepatocytes assessed as parent compound remaining after 2 hrs 来源：ChEMBL 靶标：N/A External Id：CHEMBL3269556

实验名称：Drug metabolism in human hepatocytes assessed as parent compound remaining after 2 hr... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3269558

实验名称：Binding affinity to human CB2 receptor 来源：ChEMBL 靶标：Cannabinoid receptor 2 External Id：CHEMBL3239823

实验名称：Selectivity ratio of Ki for human CB1 receptor to Ki for human CB2 receptor 来源：ChEMBL 靶标：N/A External Id：CHEMBL3239824

实验名称：Antiproliferative activity against human HTB126 cells assessed as fluorescence units ... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL988002

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英文别名

• DMH-THC-11-OIC
• CPL-7075
• IP-751
• Ajulemic acid
• CT-3