YM-750

• 常用名: YM-750
• 英文名: YM 750
• CAS号: 138046-43-2
• 分子量: 452.63000
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₁H₃₆N₂O
• 熔点: N/A
• 闪点: N/A

YM-750用途

YM-750 是一种有效的酰基:胆固醇酰基转移酶 (ACAT) 抑制剂 (IC50=0.18 μM)。ACAT催化胆固醇和长链脂肪酰辅酶A形成胆固醇酯。

YM-750名称

• 中文名: 1-cycloheptyl-1-(9H-fluoren-2-ylmethyl)-3-(2,4,6-trimethylphenyl)urea
• 英文名: 1-cycloheptyl-1-(9H-fluoren-2-ylmethyl)-3-(2,4,6-trimethylphenyl)urea

YM-750生物活性

• 描述: YM-750 是一种有效的酰基:胆固醇酰基转移酶 (ACAT) 抑制剂 (IC50=0.18 μM)。ACAT催化胆固醇和长链脂肪酰辅酶A形成胆固醇酯。
• 相关类别:
  研究领域 >> 心血管疾病
• 体外研究: 泡沫细胞在不含Cu2+的acLDL存在下积累酯化胆固醇(EC)24小时,这被KY-455和YM-750抑制[3]。
• 参考文献:

  [1]. Nagata Y, et al. N-[2-[N'-pentyl-(6,6-dimethyl-2,4-heptadiynyl)amino]ethyl]- (2-methyl-1-naphthylthio)acetamide (FY-087). A new acyl coenzyme a:cholesterol acyltransferase (ACAT) inhibitor of diet-induced atherosclerosis formation in mice. Biochem Pharmacol. 1995;49(5):643-651.

  [2]. Chang C, et al. Human acyl-CoA:cholesterol acyltransferase (ACAT) and its potential as a target for pharmaceutical intervention against atherosclerosis. Acta Biochim Biophys Sin (Shanghai). 2006;38(3):151-156.

  [3]. Miike T, et al. Effects of an anti-oxidative ACAT inhibitor on apoptosis/necrosis and cholesterol accumulation under oxidative stress in THP-1 cell-derived foam cells. Life Sci. 2008;82(1-2):79-84.

YM-750物理化学性质

• 分子式: C₃₁H₃₆N₂O
• 分子量: 452.63000
• 精确质量: 452.28300
• PSA: 35.83000
• LogP: 7.95350
• InChIKey: FMLJREWZCZHGGW-UHFFFAOYSA-N
• SMILES: Cc1cc(C)c(NC(=O)N(Cc2ccc3c(c2)Cc2ccccc2-3)C2CCCCCC2)c(C)c1
• 外观性状: 固体
• 储存条件: 2-8°C，密封，干燥

YM-750靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

共26条，当前第1页，共3页

1

2

3

YM-750英文别名

• ym 750