VPS34-IN1

• 常用名: VPS34-IN1
• 英文名: Vps34-IN-1
• CAS号: 1383716-33-3
• 分子量: 425.915
• 密度: 1.4±0.1 g/cm3
• 沸点: 693.8±65.0 °C at 760 mmHg
• 分子式: C₂₁H₂₄ClN₇O
• 熔点: N/A
• 闪点: 373.4±34.3 °C

VPS34-IN1用途

Vps34-IN-1是 Vps34 的抑制剂,来自从专利WO2012085815A1,化合物实例16a, IC50 为4nM。

VPS34-IN1名称

• 中文名: VPS34-IN-1
• 英文名: 1-(2-(2-chloropyridin-4-ylamino)-4'-(cyclopropylmethyl)-4,5'-bipyrimidin-2'-ylamino)-2-methylpropan-2-ol

VPS34-IN1生物活性

• 描述: Vps34-IN-1是 Vps34 的抑制剂,来自从专利WO2012085815A1,化合物实例16a, IC50 为4nM。
• 相关类别:
  研究领域 >> 癌症
• 靶点实验:

  Vps34:4 nM (IC50)

• 参考文献:

  [1]. WO/2012085815 A1

VPS34-IN1物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 693.8±65.0 °C at 760 mmHg
• 分子式: C₂₁H₂₄ClN₇O
• 分子量: 425.915
• 闪点: 373.4±34.3 °C
• 精确质量: 425.173096
• LogP: 3.70
• InChIKey: AWNXKZVIZARMME-UHFFFAOYSA-N
• SMILES: CC(C)(O)CNc1ncc(-c2ccnc(Nc3ccnc(Cl)c3)n2)c(CC2CC2)n1
• 外观性状: 粉末
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.689
• 储存条件: -20℃

VPS34-IN1靶点实验

查看更多实验

实验名称：Inhibition of SARS-CoV-2-induced cytopathy was measured 4 days after infection of EGF... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL5303712

实验名称：Inhibition of recombinant human N-terminal GST-tagged RIPK2 (2 to 311 residues) expre... 来源：ChEMBL 靶标：Receptor-interacting serine/threonine-protein kinase 2 External Id：CHEMBL5709617

实验名称：Inhibition of recombinant human N-terminal GST-tagged TAO1 (1 to 356 residues) expres... 来源：ChEMBL 靶标：Serine/threonine-protein kinase TAO1 External Id：CHEMBL5709616

实验名称：Inhibition of recombinant human N-terminal His6-tagged TrkA (441 to 760 residues) exp... 来源：ChEMBL 靶标：High affinity nerve growth factor receptor External Id：CHEMBL5709619

实验名称：Inhibition of recombinant human N-terminal His6-tagged YES1 (1 to 543 residues) expre... 来源：ChEMBL 靶标：Tyrosine-protein kinase Yes External Id：CHEMBL5709618

实验名称：Inhibition of recombinant human N-terminal His6-tagged TAK1 (1 to 303 residues)/TAB1 ... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase 7 External Id：CHEMBL5709621

实验名称：Inhibition of recombinant human His6-tagged GSK3beta (2 to 420 residues) expressed in... 来源：ChEMBL 靶标：Glycogen synthase kinase-3 beta External Id：CHEMBL5709620

实验名称：Inhibition of human FES at 1 uM using polyEY as substrate in presence of 33P-ATP by P... 来源：ChEMBL 靶标：Tyrosine-protein kinase Fes/Fps External Id：CHEMBL5709623

实验名称：Inhibition of recombinant human N-terminal His6-tagged ERK8 (2 to 544 residues) expre... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 15 External Id：CHEMBL5709622

实验名称：Inhibition of human FGFR3 at 1 uM using polyEY as substrate in presence of 33P-ATP by... 来源：ChEMBL 靶标：Fibroblast growth factor receptor 3 External Id：CHEMBL5709625

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VPS34-IN1英文别名

• 1-({2-[(2-Chloro-4-pyridinyl)amino]-4'-(cyclopropylmethyl)-4,5'-bipyrimidin-2'-yl}amino)-2-methyl-2-propanol
• vps34-in1
• Vps34-IN-1