(E)-3-(3-溴-4,5-二羟苯基)-N-(3,4,5-三羟基苄基)丙-2-烯硫代酰胺

• 常用名: (E)-3-(3-溴-4,5-二羟苯基)-N-(3,4,5-三羟基苄基)丙-2-烯硫代酰胺
• 英文名: NT157
• CAS号: 1384426-12-3
• 分子量: 412.255
• 密度: 1.8±0.1 g/cm3
• 沸点: 660.3±65.0 °C at 760 mmHg
• 分子式: C₁₆H₁₄BrNO₅S
• 熔点: N/A
• 闪点: 353.1±34.3 °C

用途

NT157是一种选择性的IRS-1/2抑制剂IC50 为 0.3 到0.8 μM。

名称

• 中文名: NT157
• 英文名: nt-157
• 中文别名: (E)-3-(3-溴-4,5-二羟基苯基)-N-(3,4,5-三羟基苯甲基)丙-2-烯硫代酰胺

生物活性

• 描述: NT157是一种选择性的IRS-1/2抑制剂IC50 为 0.3 到0.8 μM。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> 胰岛素受体
  研究领域 >> 癌症
• 参考文献:

  [1]. Garofalo C, et al. Preclinical Effectiveness of Selective Inhibitor of IRS-1/2 NT157 in Osteosarcoma Cell Lines. Front Endocrinol (Lausanne). 2015 May 13;6:74.

  [2]. Ibuki N, et al. The tyrphostin NT157 suppresses insulin receptor substrates and augments therapeutic response of prostate cancer. Mol Cancer Ther. 2014 Dec;13(12):2827-39.

  [3]. Ishii H, et al. miR-130a and miR-145 reprogram Gr-1+CD11b+ myeloid cells and inhibit tumor metastasis through improved host immunity. Nat Commun. 2018 Jul 4;9(1):2611.

物理化学性质

• 密度: 1.8±0.1 g/cm3
• 沸点: 660.3±65.0 °C at 760 mmHg
• 分子式: C₁₆H₁₄BrNO₅S
• 分子量: 412.255
• 闪点: 353.1±34.3 °C
• 精确质量: 410.977600
• PSA: 145.27000
• LogP: 2.89
• InChIKey: NIPUPOUEGOSAAO-OWOJBTEDSA-N
• SMILES: Oc1cc(CNC(=S)C=Cc2cc(O)c(O)c(Br)c2)cc(O)c1O
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.811
• 储存条件: -20°C

靶点实验

查看更多实验

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实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

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英文别名

• (2E)-3-(3-Bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)-2-propenethioamide
• (E)-3-(3-bromo-4,5-dihydroxyphenyl)-N-(3,4,5-trihydroxybenzyl)prop-2-enethioamide
• NT157