Lexipafant

• 常用名: Lexipafant
• 英文名: Lexipafant
• CAS号: 139133-26-9
• 分子量: 458.57400
• 密度: 1.24g/cm3
• 沸点: 639.3ºC at 760 mmHg
• 分子式: C₂₃H₃₀N₄O₄S
• 熔点: N/A
• 闪点: 340.5ºC

Lexipafant用途

利昔帕芬是一种血小板活化因子(PAF)拮抗剂,可抑制炎症反应,用于治疗急性胰腺炎。

Lexipafant名称

• 中文名: BB-882
• 英文名: Ethyl N-methyl-N-({4-[(2-methyl-1H-imidazo[4,5-c]pyridin-1-yl)met hyl]phenyl}sulfonyl)-L-leucinate

Lexipafant生物活性

• 描述: 利昔帕芬是一种血小板活化因子(PAF)拮抗剂,可抑制炎症反应,用于治疗急性胰腺炎。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Kingsnorth AN, Galloway SW, Formela LJ. Randomized, double-blind phase II trial of Lexipafant, a platelet-activating factor antagonist, in human acute pancreatitis. Br J Surg. 1995;82(10):1414-1420.

  [2]. Galloway SW, Kingsnorth AN. Lung injury in the microembolic model of acute pancreatitis and amelioration by lexipafant (BB-882), a platelet-activating factor antagonist. Pancreas. 1996;13(2):140-146.

Lexipafant物理化学性质

• 密度: 1.24g/cm3
• 沸点: 639.3ºC at 760 mmHg
• 分子式: C₂₃H₃₀N₄O₄S
• 分子量: 458.57400
• 闪点: 340.5ºC
• 精确质量: 458.19900
• PSA: 102.77000
• LogP: 4.46710
• InChIKey: AQRXDPFOYJSPMP-QFIPXVFZSA-N
• SMILES: CCOC(=O)C(CC(C)C)N(C)S(=O)(=O)c1ccc(Cn2c(C)nc3cnccc32)cc1
• 蒸汽压: 3.05E-16mmHg at 25°C
• 折射率: 1.601
• 储存条件: 2-8°C，密封，干燥

Lexipafant靶点实验

查看更多实验

实验名称：Dosage required to inhibit PAF-induced mortality in mice by 50% through oral administ... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL721819

实验名称：Dosage required to inhibit PAF-induced mortality in mice by 50% through intravenous r... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL721818

实验名称：Concentration required to inhibit PAF-induced maximum platelet aggregation in rabbit ... 来源：ChEMBL 靶标：Oryctolagus cuniculus External Id：CHEMBL769495

实验名称：Bioavailability in monkey 来源：ChEMBL 靶标：N/A External Id：CHEMBL629696

实验名称：Bioavailability in rat 来源：ChEMBL 靶标：N/A External Id：CHEMBL629698

实验名称：Dose required to reduce the lowering of the arterial blood pressure caused by PAF by ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL785741

实验名称：Percentage of inhibition by the compound against PAF-induced mortality in mice 5 hr a... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL873152

实验名称：The compound was evaluated for its PAF-induced vascular permeability in rat when dose... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL784572

实验名称：Percentage of inhibition by the compound against PAF-induced mortality in mice 3 hr a... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL879287

实验名称：Inhibition of PAF-induced platelet aggregation in whole blood obtained after 4 hr fro... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL672876

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