美托哌丙嗪

• 常用名: 美托哌丙嗪
• 英文名: Metopimazine
• CAS号: 14008-44-7
• 分子量: 445.598
• 密度: 1.4±0.1 g/cm3
• 沸点: 679.0±65.0 °C at 760 mmHg
• 分子式: C₂₂H₂₇N₃O₃S₂
• 熔点: 170.5℃
• 闪点: 364.4±34.3 °C

美托哌丙嗪用途

Metopimazine(EXP999)是一种吩噻嗪衍生物,用于预防化疗期间呕吐。Metopimazine属于抗多巴胺能抗呕吐药(ADA)类。Metopimazine可用于胃肠炎(GE)的研究[1]。

美托哌丙嗪名称

• 中文名: 美托哌丙嗪
• 英文名: 1-[3-(2-methylsulfonylphenothiazin-10-yl)propyl]piperidine-4-carboxamide
• 中文别名: 1-[3-[2-(甲基磺酰基)-10H-吩噻嗪-10-基]丙基]哌啶-4-甲酰胺

美托哌丙嗪生物活性

• 描述: Metopimazine(EXP999)是一种吩噻嗪衍生物,用于预防化疗期间呕吐。Metopimazine属于抗多巴胺能抗呕吐药(ADA)类。Metopimazine可用于胃肠炎(GE)的研究[1]。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Victoire Roussel, et al. Estimating the excess of inappropriate prescriptions of anti-dopaminergic anti-emetics during acute gastroenteritis epidemics in France. Pharmacoepidemiol Drug Saf. 2013 Oct;22(10):1080-5.

美托哌丙嗪物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 679.0±65.0 °C at 760 mmHg
• 熔点: 170.5℃
• 分子式: C₂₂H₂₇N₃O₃S₂
• 分子量: 445.598
• 闪点: 364.4±34.3 °C
• 精确质量: 445.149384
• PSA: 117.39000
• LogP: 3.19
• InChIKey: BQDBKDMTIJBJLA-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)c1ccc2c(c1)N(CCCN1CCC(C(N)=O)CC1)c1ccccc1S2
• 外观性状: 白色固体
• 蒸汽压: 0.0±2.2 mmHg at 25°C
• 折射率: 1.681
• 储存条件: 2-8°C，干燥，密闭

美托哌丙嗪毒性和生态

美托哌丙嗪安全信息

• 海关编码: 2934300000

美托哌丙嗪海关

• 海关编码: 2934300000
• 中文概述: 2934300000. 含一个吩噻嗪环系的化合物(吩噻嗪环系不论是否氢化,化合物未经进一步稠合的 ). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

美托哌丙嗪靶点实验

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实验名称：Oral bioavailability in human 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL926687

实验名称：Moderate liver toxicity, defined via clinical-chemistry results: ALT or AST serum act... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3137722

实验名称：Highest frequency of moderate liver toxicity observed during clinical trials, express... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3137723

实验名称：Acute liver toxicity defined via clinical observations and clear clinical-chemistry r... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137724

实验名称：Highest frequency of acute liver toxicity observed during clinical trials, expressed ... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL3137725

实验名称：Cytolytic liver toxicity, either proven histopathologically or where the ratio of max... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137726

实验名称：Choleostatic liver toxicity, either proven histopathologically or where the ratio of ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137727

实验名称：Severe hepatitis, defined as possibly life-threatening liver failure or through clini... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137728

实验名称：Radioligand Binding Assay from US Patent US9132134: "Methods for treating GI tract di... 来源：BindingDB 靶标：N/A External Id：BindingDB_7185_1

实验名称：Chronic liver disease either proven histopathologically, or through a chonic elevatio... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3137729

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美托哌丙嗪英文别名

• 1-[3-[2-(Methylsulfonyl)phenothiazin-10-yl]propyl]isonipecotamide
• RP 9965
• Metopimazinum [INN-Latin]
• EINECS 237-818-4
• Vogalene
• 1-[3-[2-(Methylsulfonyl)phenothiazin-10-yl]propyl]-4-piperidinecarboxamide
• 1-(3-(2-(methylsulfonyl)-10-phenothiazinyl)propyl)piperidine-4-carboxamide
• 1-{3-[2-(Methylsulfonyl)-10H-phenothiazin-10-yl]propyl}-4-piperidinecarboxamide
• 1-{3-[2-(Methylsulfonyl)-10H-phenothiazin-10-yl]propyl}piperidine-4-carboxamide
• Metopimazina [INN-Spanish]
• 1-[3-[2-(Methylsulfonyl)-10H-phenothiazin-10-yl]propyl]-4-piperidinecarboxamide
• 10-[3-(4-Carbamoylpiperidino)propyl]-2-(methanesulfonyl)phenothiazine
• 1-{3-[2-(Methylsulfonyl)-10H-phenothiazin-10-yl]propyl}-4-piperidinecarboximidic acid
• Metopimazine
• EXP 999
• Nortrip
• Methopimazin