ML277

• 常用名: ML277
• 英文名: ML 277
• CAS号: 1401242-74-7
• 分子量: 471.592
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₃H₂₅N₃O₄S₂
• 熔点: N/A
• 闪点: N/A

ML277用途

ML277(CID53347902)是一新型有效、选择性K(v)7.1 钾离子通道激动剂，EC50为270nM。

ML277名称

• 中文名: ML277
• 英文名: (2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-[(4-methylphenyl) sulfonyl]-2-piperidinecarboxamide

ML277生物活性

• 描述: ML277(CID53347902)是一新型有效、选择性K(v)7.1 钾离子通道激动剂,EC50为270nM。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钾通道
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Mattmann ME, et al. Identification of (R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide, ML277, as a novel, potent and selective K(v)7.1 (KCNQ1) potassium channel activator. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5936-41.

ML277物理化学性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₂₃H₂₅N₃O₄S₂
• 分子量: 471.592
• 精确质量: 471.128632
• PSA: 128.71000
• LogP: 4.68
• InChIKey: OXQNLLVUVDAEHC-OAQYLSRUSA-N
• SMILES: COc1ccc(-c2csc(NC(=O)C3CCCCN3S(=O)(=O)c3ccc(C)cc3)n2)cc1
• 折射率: 1.631
• 储存条件: 2-8℃

ML277靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Thermal Shift Assay. Domain start/stop: M626-G740 来源：ChEMBL 靶标：Peregrin External Id：CHEMBL4650107

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Drug metabolism in human liver microsomes assessed as methoxy-O-demethylation by mass... 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL2071933

实验名称：Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily KQT member 1 External Id：CHEMBL2071936

实验名称：Activation of Kv7.1 channel expressed in CHO cells assessed as depolarization-induced... 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily KQT member 1 External Id：CHEMBL2071937

实验名称：Drug metabolism in rat liver microsomes assessed as tolyl-oxidation by mass spectroph... 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL2071934

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ML277英文别名

• (2R)-N-[4-(4-Methoxyphenyl)-1,3-thiazol-2-yl]-1-[(4-methylphenyl)sulfonyl]-2-piperidinecarboxamide
• ML-277
• ML277