PR-924

• 常用名: PR-924
• 英文名: PR-924
• CAS号: 1416709-79-9
• 分子量: 618.721
• 密度: 1.3±0.1 g/cm3
• 沸点: 969.0±65.0 °C at 760 mmHg
• 分子式: C₃₇H₃₈N₄O₅
• 熔点: N/A
• 闪点: 539.8±34.3 °C

PR-924用途

一种有效的特异性免疫蛋白酶体LMP7亚基抑制剂,IC50为25 nM,选择性比β5c,β1i,β1c,β2i和β2c亚基高100倍(IC50>3 uM)；对LMP2活性弱,对β1,β2无可检测活性,或MECL1。

PR-924名称

• 英文名: PR-924

PR-924生物活性

• 描述: 一种有效的特异性免疫蛋白酶体LMP7亚基抑制剂,IC50为25 nM,选择性比β5c,β1i,β1c,β2i和β2c亚基高100倍(IC50>3 uM)；对LMP2活性弱,对β1,β2无可检测活性,或MECL1。
• 参考文献: References 1. Parlati F, et al. Blood. 2009 Oct 15;114(16):3439-47. 2. de Bruin G, et al. J Med Chem. 2014 Jul 24;57(14):6197-209. View Related Products by Target Proteasome

PR-924物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 969.0±65.0 °C at 760 mmHg
• 分子式: C₃₇H₃₈N₄O₅
• 分子量: 618.721
• 闪点: 539.8±34.3 °C
• 精确质量: 618.284241
• LogP: 6.17
• InChIKey: ADBUEVSHEJICCM-LZNHGOJSSA-N
• SMILES: CC1=C(C(=O)NC(C)C(=O)NC(Cc2c[nH]c3ccccc23)C(=O)NC(Cc2ccccc2)C(=O)C2(C)CO2)Cc2ccccc21
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.648
• 储存条件: 2-8°C，干燥，密封

PR-924安全信息

• 危害码 (欧洲): Xi

PR-924靶点实验

查看更多实验

实验名称：Ratio of IC50 for 20s proteasome subunit beta-5c to IC50 for proteasome subunit beta-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3371287

实验名称：Ratio of IC50 for proteasome subunit beta-1i to IC50 for proteasome subunit beta-5i i... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3371288

实验名称：Inhibition of proteasome subunit beta-2i in human RPMI8226 cells using BODIPY-epoxomi... 来源：ChEMBL 靶标：Proteasome subunit beta type-10 External Id：CHEMBL3371285

实验名称：Inhibition of 20s proteasome subunit beta-2c in human RPMI8226 cells using BODIPY-epo... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3371286

实验名称：Ratio of IC50 for proteasome subunit beta-2i to IC50 for proteasome subunit beta-5i i... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3371289

实验名称：Ratio of IC50 for 20s proteasome subunit beta-2c to IC50 for proteasome subunit beta-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3371290

实验名称：Inhibition of proteasome subunit beta-5i in human Raji cells using BODIPY-NC005 by fl... 来源：ChEMBL 靶标：Proteasome subunit beta type-8 External Id：CHEMBL3371271

实验名称：Inhibition of MECL1 in mouse A20 cells by ELISA 来源：ChEMBL 靶标：Proteasome subunit beta type-10 External Id：CHEMBL4411757

实验名称：Inhibition of 20s proteasome subunit beta-5c in human Raji cells using BODIPY-NC005 b... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3371272

实验名称：Inhibition of 20S proteosome beta 2 in mouse A20 cells by ELISA 来源：ChEMBL 靶标：Proteasome subunit beta type-2 External Id：CHEMBL4411758

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PR-924英文别名

• ZI5ZER54A9
• PR-924
• 4,5-Anhydro-1,2-dideoxy-4-methyl-2-({N-[(3-methyl-1H-inden-2-yl)carbonyl]-D-alanyl-L-tryptophyl}amino)-1-phenyl-D-erythro-pent-3-ulose