1,4-伸苯基双(1,4'-二哌啶-1'-基甲酮)

• 常用名: 1,4-伸苯基双(1,4'-二哌啶-1'-基甲酮)
• 英文名: UNC-1079
• CAS号: 1418741-86-2
• 分子量: 466.659
• 密度: 1.2±0.1 g/cm3
• 沸点: 640.0±55.0 °C at 760 mmHg
• 分子式: C₂₈H₄₂N₄O₂
• 熔点: N/A
• 闪点: 264.2±23.9 °C

用途

UNC1079是UNC1021的哌啶类似物,结构相似,但具有较低的有效抑制剂用。

名称

• 中文名: 1,4-伸苯基双(1,4'-二哌啶-1'-基甲酮)
• 英文名: 1,4-Phenylenebis(1,4'-bipiperidin-1'-ylmethanone)

生物活性

• 描述: UNC1079是UNC1021的哌啶类似物,结构相似,但具有较低的有效抑制剂用。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
• 参考文献:

  [1]. James LI, et al. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol. 2013 Mar;9(3):184-91.

物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 640.0±55.0 °C at 760 mmHg
• 分子式: C₂₈H₄₂N₄O₂
• 分子量: 466.659
• 闪点: 264.2±23.9 °C
• 精确质量: 466.330780
• LogP: 2.28
• InChIKey: HOUMUCTZMMLNTR-UHFFFAOYSA-N
• SMILES: O=C(c1ccc(C(=O)N2CCC(N3CCCCC3)CC2)cc1)N1CCC(N2CCCCC2)CC1
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.590
• 储存条件: 2-8℃

靶点实验

查看更多实验

实验名称：Binding affinity to GFP-tagged full length L3MBTL3 (unknown origin) assessed as disso... 来源：ChEMBL 靶标：Lethal(3)malignant brain tumor-like protein 3 External Id：CHEMBL5712171

实验名称：Binding affinity to GFP-3MBT tagged L3MBTL3 (unknown origin) assessed as dissociation... 来源：ChEMBL 靶标：Lethal(3)malignant brain tumor-like protein 3 External Id：CHEMBL5712175

实验名称：Cytotoxicity in HEK293T/17 cells assessed as effect on cell viability up to 100 uM in... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5712114

实验名称：Inhibition of GFP-3MBT tagged L3MBTL3 (unknown origin) expressed in HEK293 cells asse... 来源：ChEMBL 靶标：Lethal(3)malignant brain tumor-like protein 3 External Id：CHEMBL5712118

实验名称：Inhibition of JARID1A (unknown origin) after 30 mins by AlphaScreen assay 来源：ChEMBL 靶标：Lysine-specific demethylase 5A External Id：CHEMBL2429070

实验名称：Inhibition of GFP-3MBT tagged L3MBTL3 (unknown origin) expressed in HEK293 cells asse... 来源：ChEMBL 靶标：Lethal(3)malignant brain tumor-like protein 3 External Id：CHEMBL5712121

实验名称：Inhibition of MBTD1 (unknown origin) after 30 mins by AlphaScreen assay 来源：ChEMBL 靶标：MBT domain-containing protein 1 External Id：CHEMBL2429074

实验名称：Inhibition of UHRF1 (unknown origin) after 30 mins by AlphaScreen assay 来源：ChEMBL 靶标：E3 ubiquitin-protein ligase UHRF1 External Id：CHEMBL2429073

实验名称：Inhibition of 53BP1 (unknown origin) after 30 mins by AlphaScreen assay 来源：ChEMBL 靶标：TP53-binding protein 1 External Id：CHEMBL2429072

实验名称：Inhibition of PHF23 (unknown origin) after 30 mins by AlphaScreen assay 来源：ChEMBL 靶标：PHD finger protein 23 External Id：CHEMBL2429071

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英文别名

• 1,4-Phenylenebis(1,4'-bipiperidin-1'-ylmethanone)
• UNC-1079
• UNC1079