IWP-L6

• 常用名: IWP-L6
• 英文名: IWP L6
• CAS号: 1427782-89-5
• 分子量: 472.582
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₅H₂₀N₄O₂S₂
• 熔点: N/A
• 闪点: N/A

IWP-L6用途

IWP L6是高活性Porcn抑制剂,EC50为0.5 nM。

IWP-L6名称

• 中文名: N-(5-苯基-2-吡啶基)-2-[(3,4,6,7-四氢-4-氧代-3-苯基噻吩并[3,2-d]嘧啶-2-基)硫基]乙酰胺
• 英文名: 2-[(4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl) sulfanyl]-N-(5-phenyl-2-pyridinyl)acetamide

IWP-L6生物活性

• 描述: IWP L6是高活性Porcn抑制剂,EC50为0.5 nM。
• 相关类别:
  信号通路 >> 干细胞及 Wnt 通路 >> 豪猪
  研究领域 >> 癌症
• 参考文献:

  [1]. Wang, X., et al., The development of highly potent inhibitors for porcupine. J Med Chem, 2013. 56(6): p. 2700-4.

IWP-L6物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₂₅H₂₀N₄O₂S₂
• 分子量: 472.582
• 精确质量: 472.102753
• PSA: 130.97000
• LogP: 5.64
• InChIKey: QESQGTFWEQMCMH-UHFFFAOYSA-N
• SMILES: O=C(CSc1nc2c(c(=O)n1-c1ccccc1)SCC2)Nc1ccc(-c2ccccc2)cn1
• 外观性状: 粉末
• 折射率: 1.727
• 储存条件: -20℃

IWP-L6靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：ASTRAZENECA: % bound to plasma by equilibrium dialysis. Compound is incubated with wh... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301365

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by Spri... 来源：ChEMBL 靶标：Protein-serine O-palmitoleoyltransferase porcupine External Id：CHEMBL2330993

实验名称：Inhibition of porcupine-mediated phosphorylation of dishevelled 2 in HEK293 cells at ... 来源：ChEMBL 靶标：Protein-serine O-palmitoleoyltransferase porcupine External Id：CHEMBL2330992

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

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IWP-L6英文别名

• 2-[(4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]-N-(5-phenyl-2-pyridinyl)acetamide
• IWP L6