OXF BD 02

• 常用名: OXF BD 02
• 英文名: OXF BD 02
• CAS号: 1429129-68-9
• 分子量: 295.33
• 密度: 1.2±0.1 g/cm3
• 沸点: 515.4±50.0 °C at 760 mmHg
• 分子式: C₁₈H₁₇NO₃
• 熔点: N/A
• 闪点: 265.5±30.1 °C

OXF BD 02用途

OXF BD 02是BRD4(1)(BRD4的第一个溴代烷)的选择性抑制剂,IC50值为382 nM【1】。

OXF BD 02名称

• 英文名: 3-(3,5-Dimethyl-1,2-oxazol-4-yl)-5-[hydroxy(phenyl)methyl]phenol

OXF BD 02生物活性

• 描述: OXF BD 02是BRD4(1)(BRD4的第一个溴代烷)的选择性抑制剂,IC50值为382 nM【1】。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 表观遗传学 >> 表观遗传读者域
• 靶点实验:

  BRD4(1):382 nM (IC50)

• 参考文献:

  [1]. Hewings DS, et al. Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. J Med Chem. 2013 Apr 25;56(8):3217-27.

OXF BD 02物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 515.4±50.0 °C at 760 mmHg
• 分子式: C₁₈H₁₇NO₃
• 分子量: 295.33
• 闪点: 265.5±30.1 °C
• 精确质量: 295.120850
• LogP: 2.54
• InChIKey: FEQUIPXIENTMJN-UHFFFAOYSA-N
• SMILES: Cc1noc(C)c1-c1cc(O)cc(C(O)c2ccccc2)c1
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.616

OXF BD 02靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

实验名称：Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve... 来源：NCGC 靶标：N/A External Id：OBG420

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-2C

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-9B

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant ... 来源：NCGC External Id：s-sky_synergy-MV-411_DR-CTG72-MIPE_NPC_NPACT_Kinase-p1

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) naive MV4-11 ce... 来源：NCGC External Id：s-sky_synergy-MV-411_N-CTG72-MIPE_NPC_NPACT_Kinase-p1

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OXF BD 02英文别名

• 3-(3,5-Dimethyl-1,2-oxazol-4-yl)-5-[hydroxy(phenyl)methyl]phenol