CB1-IN-1

• 常用名: CB1-IN-1
• 英文名: CB1-IN-1
• CAS号: 1429239-98-4
• 分子量: 751.669
• 密度: 1.5±0.1 g/cm3
• 沸点: N/A
• 分子式: C₃₃H₃₁Cl₂F₃N₆O₃S₂
• 熔点: N/A
• 闪点: N/A

CB1-IN-1用途

CB1-IN-1是一种新型外周大麻素-1受体 (CB1R) 拮抗剂,作用于CB1R (EC50 = 3 nM) 和 CB2R, Ki值分别为0.3 nM 和 21 nM。

CB1-IN-1名称

• 中文名: CB1-IN-1
• 英文名: 1-(2,4-Dichlorophenyl)-N-(1-piperidinyl)-4-{[(1-pyrrolidinylsulfonyl)amino]methyl}-5-(5-{[4-(trifluoromethyl)phenyl]ethynyl}-2-thienyl)-1H-pyrazole-3-carboxamide

CB1-IN-1生物活性

• 描述: CB1-IN-1是一种新型外周大麻素-1受体 (CB1R) 拮抗剂,作用于CB1R (EC50 = 3 nM) 和 CB2R, Ki值分别为0.3 nM 和 21 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 大麻素受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Chang CP, et al. Discovery of 1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor anta

CB1-IN-1物理化学性质

• 密度: 1.5±0.1 g/cm3
• 分子式: C₃₃H₃₁Cl₂F₃N₆O₃S₂
• 分子量: 751.669
• 精确质量: 750.122803
• LogP: 6.52
• InChIKey: KAIYFJUWIBTYPK-UHFFFAOYSA-N
• SMILES: O=C(NN1CCCCC1)c1nn(-c2ccc(Cl)cc2Cl)c(-c2ccc(C#Cc3ccc(C(F)(F)F)cc3)s2)c1CNS(=O)(=O)N1CCCC1
• 折射率: 1.672
• 储存条件: 2-8℃

CB1-IN-1靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Primary Screen for Target Class Profiling of Small Molecule Inhibitors of Methyltrans... 来源：NCGC External Id：MTASE-p

实验名称：Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve... 来源：NCGC 靶标：N/A External Id：OBG420

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-2C

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-9B

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant ... 来源：NCGC External Id：s-sky_synergy-MV-411_DR-CTG72-MIPE_NPC_NPACT_Kinase-p1

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) naive MV4-11 ce... 来源：NCGC External Id：s-sky_synergy-MV-411_N-CTG72-MIPE_NPC_NPACT_Kinase-p1

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：Primary qHTS for Inhibitors of N-terminal methyltransferase 1 (NTMT1): MTaseGlo Assay 来源：NCGC External Id：NTMT1-p-MTaseGlo

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

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CB1-IN-1英文别名

• 1-(2,4-Dichlorophenyl)-N-(1-piperidinyl)-4-{[(1-pyrrolidinylsulfonyl)amino]methyl}-5-(5-{[4-(trifluoromethyl)phenyl]ethynyl}-2-thienyl)-1H-pyrazole-3-carboxamide
• CB1-IN-1