去甲右美沙芬酒石酸盐

• 常用名: 去甲右美沙芬酒石酸盐
• 英文名: Dextrorphan tartrate
• CAS号: 143-98-6
• 分子量: 407.457
• 密度: N/A
• 沸点: 410.4ºC at 760 mmHg
• 分子式: C₂₁H₂₉NO₇
• 熔点: 201-204°C
• 闪点: 207.2ºC
• 符号: GHS02, GHS06, GHS08
• 信号词: Danger

去甲右美沙芬酒石酸盐用途

Dextrophan tartrate is a glutamate receptor antagonist potentially for the treatment of stroke. Dextrorphan (DXO) is a psychoactive drug of the morphinan chemical class which acts as an antitussive or cough suppressant and dissociative hallucinogen. It is the dextrorotatory-stereoisomer of racemorphan, the levo-half being levorphanol. Dextrorphan is produced by O-demethylation of dextromethorphan by CYP2D6. Dextrorphan is an NMDA antagonist and contributes to the psychoactive effects of dextromethorphan.

去甲右美沙芬酒石酸盐名称

• 中文名: 去甲右美沙芬酒石酸盐
• 英文名: Dextrorphan tartrate

去甲右美沙芬酒石酸盐物理化学性质

• 沸点: 410.4ºC at 760 mmHg
• 熔点: 201-204°C
• 分子式: C₂₁H₂₉NO₇
• 分子量: 407.457
• 闪点: 207.2ºC
• 精确质量: 407.194397
• PSA: 138.53000
• LogP: 0.89570
• InChIKey: RWTWIZDKEIWLKQ-XCPWPWHNSA-N
• SMILES: CN1CCC23CCCCC2C1Cc1ccc(O)cc13.O=C(O)C(O)C(O)C(=O)O
• 外观性状: white
• 蒸汽压: 2.55E-07mmHg at 25°C
• 储存条件:

  −70℃

• 水溶解性: H2O: >10mg/mL
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:5

  3.氢键受体数量:8

  4.可旋转化学键数量:3

  5.互变异构体数量:3

  6.拓扑分子极性表面积139

  7.重原子数量:29

  8.表面电荷:0

  9.复杂度:491

  10.同位素原子数量:0

  11.确定原子立构中心数量:5

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:2

去甲右美沙芬酒石酸盐毒性和生态

去甲右美沙芬酒石酸盐安全信息

• 符号: GHS02, GHS06, GHS08
• 信号词: Danger
• 危害声明: H225-H301 + H311 + H331-H370
• 警示性声明: P210-P260-P280-P301 + P310-P311
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xn
• 风险声明 (欧洲): R22
• 安全声明 (欧洲): 7-16-36/37-45
• 危险品运输编码: UN1230 - class 3 - PG 2 - Methanol, solution
• RTECS号: QD1930000

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去甲右美沙芬酒石酸盐英文别名

• (2R,3R)-2,3-Dihydroxysuccinic acid - (9α,13α,14α)-17-methylmorphinan-3-ol (1:1)
• Levorphanol tartrate
• 1,3,4,9,10,10a-Hexahydro-11-methyl-2H-10,4a-iminoethanophenanthren-6-ol tartrate,d
• d-1,3,4,9,10,10a-Hexahydro-11-methyl-2H-10,4a-iminoethanophenanthren-6-ol Tartrate
• Dextrorphan Tartrate Salt
• 17-Methyl-morphinan-3-ol,Lg-Hydrogentartrat
• d-3-Hydroxy-N-methylmorphinan tartrate
• Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with (9α,13α,14α)-17-methylmorphinan-3-ol (1:1)
• 17-methyl-morphinan-3-ol,Lg-hydrogentartrate
• MFCD00151495
• (+)-(9a,13a,14a)-17-methylmorphinan-3-ol Tartrate (1:1) (Salt)
• Dextrophan tartrate