藜芦嗪

• 常用名: 藜芦嗪
• 英文名: verazine
• CAS号: 14320-81-1
• 分子量: 397.64
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₄₃NO
• 熔点: N/A
• 闪点: N/A

藜芦嗪用途

Verazine ((-)-Verazine) 是一种抗真菌 (Fungal) 剂,可从干燥毛穗藜芦的根和根茎部获得。Verazine 还能以剂量依赖性的方式导致小鼠小脑和大脑皮层的 DNA 损伤。Verazine 可用于真菌感染以及神经疾病的研究。

藜芦嗪名称

• 中文名: 藜芦嗪
• 英文名: verazine

藜芦嗪生物活性

• 描述: Verazine ((-)-Verazine) 是一种抗真菌 (Fungal) 剂,可从干燥毛穗藜芦的根和根茎部获得。Verazine 还能以剂量依赖性的方式导致小鼠小脑和大脑皮层的 DNA 损伤。Verazine 可用于真菌感染以及神经疾病的研究。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 真菌
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Cong Y, et al. Steroidal Alkaloids from Veratrum maackii Regel with Genotoxicity on Brain-Cell DNA in Mice. Helv Chim Acta. 2015, 98(4): 539-545.

  [2]. Augustin MM, et al. Elucidating steroid alkaloid biosynthesis in Veratrum californicum: production of verazine in Sf9 cells. Plant J. 2015 Jun;82(6):991-1003.

藜芦嗪物理化学性质

• 分子式: C₂₇H₄₃NO
• 分子量: 397.64
• 精确质量: 397.33400
• PSA: 32.59000
• LogP: 5.86890
• InChIKey: VRBNGKPRTHBEIQ-LURFOZDGSA-N
• SMILES: CC1CCC(C(C)C2CCC3C4CC=C5CC(O)CCC5(C)C4CCC23C)=NC1

藜芦嗪靶点实验

查看更多实验

实验名称：Inhibition of hedgehog pathway in mouse Shh Light II cells transfected with Renilla l... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4822405

实验名称：Antifungal activity against Candida albicans SC5314 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL1003449

实验名称：Cytotoxicity against mouse M109 cells 来源：ChEMBL 靶标：M109 External Id：CHEMBL1003450

实验名称：Antiproliferative activity against human DAOY cells assessed as cell viability at 10 ... 来源：ChEMBL 靶标：Daoy External Id：CHEMBL4822409

实验名称：Antifungal activity against Saccharomyces cerevisiae 1353 来源：ChEMBL 靶标：Saccharomyces cerevisiae External Id：CHEMBL1003447

实验名称：Binding affinity to recombinant human Flag-6 x His-tagged Smo expressed in human HEK2... 来源：ChEMBL 靶标：Smoothened homolog External Id：CHEMBL4822406

实验名称：Antifungal activity against Saccharomyces cerevisiae Sc7 来源：ChEMBL 靶标：Saccharomyces cerevisiae External Id：CHEMBL1003448

实验名称：Binding affinity to recombinant human Flag-6 x His-tagged Smo expressed in human HEK2... 来源：ChEMBL 靶标：Smoothened homolog External Id：CHEMBL4822407

实验名称：Antifungal activity against Saccharomyces cerevisiae 1138 来源：ChEMBL 靶标：Saccharomyces cerevisiae External Id：CHEMBL1003445

实验名称：Antifungal activity against Saccharomyces cerevisiae 1140 来源：ChEMBL 靶标：Saccharomyces cerevisiae External Id：CHEMBL1003446

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藜芦嗪英文别名

• (3S,8S,9S,10R,13S,14S,17R)-10,13-Dimethyl-17-[(S)-1-((S)-5-methyl-3,4,5,6-tetrahydro-pyridin-2-yl)-ethyl]-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
• Verazin, (25S)-22,26-Imino-Δ5,22,N-cholestadien-3β-ol