CAY10677

• 常用名: CAY10677
• 英文名: CAY10677
• CAS号: 1443253-20-0
• 分子量: 407.595
• 密度: 1.1±0.1 g/cm3
• 沸点: 600.3±65.0 °C at 760 mmHg
• 分子式: C₂₅H₃₇N₅
• 熔点: N/A
• 闪点: 316.9±34.3 °C

CAY10677用途

CAY10677 (compound 15) 是强效的 ICMT 抑制剂,可抑制癌细胞增殖。CAY10677 具有良好 PAMPA 渗透性。

CAY10677名称

• 中文名: CAY10677
• 英文名: 5-{3-[(Diethylamino)methyl]-1-octyl-1H-indol-5-yl}-2-pyrimidinami ne

CAY10677生物活性

• 描述: CAY10677 (compound 15) 是强效的 ICMT 抑制剂,可抑制癌细胞增殖。CAY10677 具有良好 PAMPA 渗透性。
• 相关类别:
  研究领域 >> 癌症
• 参考文献:

  [1]. Ramanujulu PM et al. Functionalized indoleamines as potent, drug-like inhibitors of isoprenylcysteine carboxyl methyltransferase (Icmt). Eur J Med Chem. 2013 May;63:378-86.

CAY10677物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 600.3±65.0 °C at 760 mmHg
• 分子式: C₂₅H₃₇N₅
• 分子量: 407.595
• 闪点: 316.9±34.3 °C
• 精确质量: 407.304901
• PSA: 60.70000
• LogP: 6.48
• InChIKey: HKAUEDVXIIXVGY-UHFFFAOYSA-N
• SMILES: CCCCCCCCn1cc(CN(CC)CC)c2cc(-c3cnc(N)nc3)ccc21
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.585
• 储存条件: -20°C，密闭，干燥

CAY10677靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Confirmatory qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinas... 来源：NCGC External Id：IP6K1-f1-cherrypicks

实验名称：Primary Screen for Target Class Profiling of Small Molecule Inhibitors of Methyltrans... 来源：NCGC External Id：MTASE-p

实验名称：Inhibition of recombinant Icmt (unknown origin) expressed in Sf9 cells assessed as tr... 来源：ChEMBL 靶标：Protein-S-isoprenylcysteine O-methyltransferase External Id：CHEMBL2380129

实验名称：Primary qHTS to identify gynecologic anti-cancer compounds using libraries of approve... 来源：NCGC 靶标：N/A External Id：OBG420

实验名称：Antiproliferative activity against human MDA-MB-231 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL2380128

实验名称：Antiproliferative activity against human PC3 cells after 72 hrs by MTT assay 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL2380127

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-2C

实验名称：Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) i... 来源：NCGC External Id：NSD2-synergy-p-9B

实验名称：Viability qHTS for spleen associated tyrosine kinase inhibitor (SYKi) drug resistant ... 来源：NCGC External Id：s-sky_synergy-MV-411_DR-CTG72-MIPE_NPC_NPACT_Kinase-p1

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CAY10677英文别名

• 5-{3-[(Diethylamino)methyl]-1-octyl-1H-indol-5-yl}-2-pyrimidinamine