1-[6-(Acetylamino)-6-deoxy-I(2)-D-glucopyranosyl]-4-chloro-3-[(4-cyclopropylphenyl)methyl]-1H-indole

• 常用名: 1-[6-(Acetylamino)-6-deoxy-I(2)-D-glucopyranosyl]-4-chloro-3-[(4-cyclopropylphenyl)methyl]-1H-indole
• 英文名: 1-[6-(Acetylamino)-6-deoxy-I(2)-D-glucopyranosyl]-4-chloro-3-[(4-cyclopropylphenyl)methyl]-1H-indole
• CAS号: 1443333-67-2
• 分子量: 485.0
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₉ClN₂O₅
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 1-[6-(Acetylamino)-6-deoxy-I(2)-D-glucopyranosyl]-4-chloro-3-[(4-cyclopropylphenyl)methyl]-1H-indole

物理化学性质

• 分子式: C₂₆H₂₉ClN₂O₅
• 分子量: 485.0
• InChIKey: BILGTWHYSCNCRU-XDXGNBCUSA-N
• SMILES: CC(=O)NCC1OC(n2cc(Cc3ccc(C4CC4)cc3)c3c(Cl)cccc32)C(O)C(O)C1O

靶点实验

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实验名称：Effect on glucose AUC in Sprague-Dawley rat at 50 mg/kg, po administered as single do... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3792106

实验名称：Reduction of blood glucose level in Sprague-Dawley rat at 50 mg/kg, po administered a... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3792105

实验名称：Induction of glucosuria in Sprague-Dawley rat assessed as increase in glucose excreti... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3790123

实验名称：Half life in Sprague-Dawley rat at 1.1 mg/kg, iv administered via bolus injection by ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3790127

实验名称：Selectivity ratio of EC50 for human SGLT1 expressed in CHO-K1 cells to EC50 for human... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3790126

实验名称：Inhibition of human SGLT1 expressed in CHO-K1 cells assessed as reduction in [14C]AMG... 来源：ChEMBL 靶标：Sodium/glucose cotransporter 1 External Id：CHEMBL3790125

实验名称：Inhibition of human SGLT2 expressed in CHO-K1 cells assessed as reduction in [14C]AMG... 来源：ChEMBL 靶标：Sodium/glucose cotransporter 2 External Id：CHEMBL3790124

实验名称：Half life in Sprague-Dawley rat at 1.1 mg/kg, po by LC-MS/MS analysis 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3790398

实验名称：AUC (0 to infinity) in Sprague-Dawley rat at 1.1 mg/kg, iv administered via bolus inj... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3790397

实验名称：Clearance in Sprague-Dawley rat at 1.1 mg/kg, iv administered via bolus injection mea... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3790129

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