ML314

• 常用名: ML314
• 英文名: ML314
• CAS号: 1448895-09-7
• 分子量: 420.504
• 密度: 1.2±0.1 g/cm3
• 沸点: 496.1±45.0 °C at 760 mmHg
• 分子式: C₂₄H₂₈N₄O₃
• 熔点: N/A
• 闪点: 253.8±28.7 °C

ML314用途

ML314是NTR1激动剂,EC50为1.9 μM,对NTR2和GPR35抑制性较弱,不能刺激钙离子转移。

ML314名称

• 中文名: ML314
• 英文名: 2-cyclopropyl-6,7-dimethoxy-4-(4-(2-methoxyphenyl)piperazin-1-yl)quinazoline

ML314生物活性

• 描述: ML314是NTR1激动剂,EC50为1.9 μM,对NTR2和GPR35抑制性较弱,不能刺激钙离子转移。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 神经降压素受体
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Hershberger P, et al. Small Molecule Agonists for the Neurotensin 1 Receptor (NTR1 Agonists). Probe Reports from the NIH Molecular Libraries Program

ML314物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 496.1±45.0 °C at 760 mmHg
• 分子式: C₂₄H₂₈N₄O₃
• 分子量: 420.504
• 闪点: 253.8±28.7 °C
• 精确质量: 420.216156
• PSA: 59.95000
• LogP: 2.49
• InChIKey: SWEOAXMICIJCQC-UHFFFAOYSA-N
• SMILES: COc1cc2nc(C3CC3)nc(N3CCN(c4ccccc4OC)CC3)c2cc1OC
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.633
• 储存条件: 2-8℃

ML314靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Allosteric modulation of human PK-tagged Gi/Go-coupled KOR expressed in CHOK1 cells a... 来源：ChEMBL 靶标：Kappa-type opioid receptor External Id：CHEMBL4375484

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Ratio of drug level in brain to plasma of C57BL/6J mouse brain at 30 mg/kg, ip after ... 来源：ChEMBL 靶标：Nucleic Acid External Id：CHEMBL2433102

实验名称：Allosteric modulation of human PK-tagged Gi/Go-coupled GPR35 expressed in CHOK1 cells... 来源：ChEMBL 靶标：G-protein coupled receptor 35 External Id：CHEMBL4375482

实验名称：Allosteric modulation of human PK-tagged Gq-coupled GPR55 expressed in CHOK1 cells as... 来源：ChEMBL 靶标：G-protein coupled receptor 55 External Id：CHEMBL4375483

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

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ML314英文别名

• 2-Cyclopropyl-6,7-dimethoxy-4-[4-(2-methoxyphenyl)-1-piperazinyl]quinazoline
• ML314