DDR1-IN-1

• 常用名: DDR1-IN-1
• 英文名: DDR1-IN-1
• CAS号: 1449685-96-4
• 分子量: 552.587
• 密度: 1.3±0.1 g/cm3
• 沸点: 609.0±55.0 °C at 760 mmHg
• 分子式: C₃₀H₃₁F₃N₄O₃
• 熔点: N/A
• 闪点: 322.1±31.5 °C

DDR1-IN-1用途

DDR1-IN-1是DDR1受体酪氨酸激酶抑制剂，IC50和EC50分别为105 nM和87 nM，而对DDR2的IC50为413 nM。

DDR1-IN-1名称

• 中文名: N-[3-[(2,3-二氢-2-氧代-1H-吲哚-5-基)氧基]-4-甲基苯基]-4-[(4-乙基-1-哌嗪基)甲基]-3-(三氟甲基)苯甲酰胺
• 英文名: N-[3-[(2,3-Dihydro-2-oxo-1H-indol-5-yl)oxy]-4-methylphenyl]-4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluoromethyl)benzamide

DDR1-IN-1生物活性

• 描述: DDR1-IN-1是DDR1受体酪氨酸激酶抑制剂,IC50和EC50分别为105 nM和87 nM,而对DDR2的IC50为413 nM。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> 盘基蛋白结构域受体
  研究领域 >> 癌症
• 参考文献:

  [1]. Kim HG, et al. Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. ACS Chem Biol. 2013 Oct 18;8(10):2145-50.

DDR1-IN-1物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 609.0±55.0 °C at 760 mmHg
• 分子式: C₃₀H₃₁F₃N₄O₃
• 分子量: 552.587
• 闪点: 322.1±31.5 °C
• 精确质量: 552.234802
• LogP: 4.70
• InChIKey: AOZPVMOOEJAZGK-UHFFFAOYSA-N
• SMILES: CCN1CCN(Cc2ccc(C(=O)Nc3ccc(C)c(Oc4ccc5c(c4)CC(=O)N5)c3)cc2C(F)(F)F)CC1
• 外观性状: 粉末
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.602
• 储存条件: -20℃

DDR1-IN-1靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Human discoidin domain receptor tyrosine kinase 1 (Type XVI RTKs: DDR (collagen recep... 来源：IUPHAR-DB 靶标：discoidin domain receptor tyrosine kinase 1 (Type XVI RTKs: DDR (collagen receptor) family) [Homo sapiens] External Id：1843_Human

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

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DDR1-IN-1英文别名

• 4-[(4-Ethyl-1-piperazinyl)methyl]-N-{4-methyl-3-[(2-oxo-2,3-dihydro-1H-indol-5-yl)oxy]phenyl}-3-(trifluoromethyl)benzamide
• DDR1-IN-1