PFK-158

• 常用名: PFK-158
• 英文名: PFK-158
• CAS号: 1462249-75-7
• 分子量: 328.288
• 密度: 1.3±0.1 g/cm3
• 沸点: 466.3±45.0 °C at 760 mmHg
• 分子式: C₁₈H₁₁F₃N₂O
• 熔点: N/A
• 闪点: 235.8±28.7 °C

PFK-158用途

PFK-158是一种有效的选择性PFKFB3抑制剂,目前对晚期实体瘤研究处于临床一期阶段。

PFK-158名称

• 中文名: PFK-158
• 英文名: PFK-158

PFK-158生物活性

• 描述: PFK-158是一种有效的选择性PFKFB3抑制剂,目前对晚期实体瘤研究处于临床一期阶段。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
• 参考文献:

  [1]. Rebecca Redman, et al. Abstract CT206: PFK-158, first-in-man and first-in-class inhibitor of PFKFB3/ glycolysis: A phase I, dose escalation, multi-center study in patients with advanced solid malignancies. Cancer Res August 1, 2015 75; CT206. doi: 10.1158

  [2]. Sucheta Telang, et al. Discovery of a PFKFB3 inhibitor for phase I trial testing that synergizes with the B-Raf inhibitor vemurafenib. Cancer Metab. 2014; 2(Suppl 1): P14.

PFK-158物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 466.3±45.0 °C at 760 mmHg
• 分子式: C₁₈H₁₁F₃N₂O
• 分子量: 328.288
• 闪点: 235.8±28.7 °C
• 精确质量: 328.082336
• LogP: 3.55
• InChIKey: IAJOMYABKVAZCN-AATRIKPKSA-N
• SMILES: O=C(C=Cc1ccc2ccc(C(F)(F)F)cc2n1)c1ccncc1
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.624
• 储存条件: 2-8℃

PFK-158靶点实验

查看更多实验

实验名称：Synergistic antibacterial activity against carbapenem-resistant Escherichia coli 08-8... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4817953

实验名称：Synergistic antibacterial activity against carbapenem-resistant Escherichia coli 08-8... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4817954

实验名称：Cytotoxicity against human A549 cells 来源：ChEMBL 靶标：A549 External Id：CHEMBL4817951

实验名称：Antibacterial activity against carbapenem-resistant Escherichia coli 08-85 mcr-1 posi... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4817952

实验名称：Synergistic antibacterial activity against carbapenem-resistant Enterobacter cloacae ... 来源：ChEMBL 靶标：Enterobacter cloacae External Id：CHEMBL4817957

实验名称：Antibacterial activity against carbapenem-resistant Enterobacter cloacae D01 mcr-1 ne... 来源：ChEMBL 靶标：Enterobacter cloacae External Id：CHEMBL4817955

实验名称：Synergistic antibacterial activity against carbapenem-resistant Enterobacter cloacae ... 来源：ChEMBL 靶标：Enterobacter cloacae External Id：CHEMBL4817956

实验名称：Antibacterial activity against vancomycin-resistant Enterococcus faecalis ATCC 51299 ... 来源：ChEMBL 靶标：Enterococcus faecalis External Id：CHEMBL4817945

实验名称：Cellular viability qHTS for adrenocortical cancer (ACC) cell line SW-13 来源：NCGC 靶标：N/A External Id：ACC-ATC-p1-SW13-72hr

实验名称：Antibacterial activity against ESBLs positive Escherichia coli ATCC 35218 by agar met... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4817946

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PFK-158英文别名

• (2E)-1-(4-Pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-2-propen-1-one