DprE1-IN-1

• 常用名: DprE1-IN-1
• 英文名: DprE1-IN-1
• CAS号: 1494675-86-3
• 分子量: 355.391
• 密度: 1.3±0.1 g/cm3
• 沸点: 691.6±55.0 °C at 760 mmHg
• 分子式: C₁₈H₂₁N₅O₃
• 熔点: N/A
• 闪点: 372.1±31.5 °C

DprE1-IN-1用途

DprE1-IN-1是一种有效的DprE1抑制剂,IC50值为10 nM, 也抑制 PDE6, IC50为6 uM。

DprE1-IN-1名称

• 中文名: N-(2-羟基乙基)-1-[(6-甲氧基-5-甲基嘧啶-4-基)甲基]-6-甲基-1H-吡咯并[3,2-b]吡啶-3-甲酰胺
• 英文名: N-(2-Hydroxyethyl)-1-[(6-methoxy-5-methylpyrimidin-4-yl)methyl]-6-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide

DprE1-IN-1生物活性

• 描述: DprE1-IN-1是一种有效的DprE1抑制剂,IC50值为10 nM, 也抑制 PDE6, IC50为6 uM。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Shirude PS, et al. Lead optimization of 1,4-azaindoles as antimycobacterial agents. J Med Chem. 2014 Jul 10;57(13):5728-37.

  [2]. Chatterji M, et al. 1,4-azaindole, a potential drug candidate for treatment of tuberculosis. Antimicrob Agents Chemother. 2014 Sep;58(9):5325-31.

DprE1-IN-1物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 691.6±55.0 °C at 760 mmHg
• 分子式: C₁₈H₂₁N₅O₃
• 分子量: 355.391
• 闪点: 372.1±31.5 °C
• 精确质量: 355.164429
• LogP: 1.37
• InChIKey: VDRYGTNDKXIPSK-UHFFFAOYSA-N
• SMILES: COc1ncnc(Cn2cc(C(=O)NCCO)c3ncc(C)cc32)c1C
• 蒸汽压: 0.0±2.3 mmHg at 25°C
• 折射率: 1.650
• 储存条件: 2-8℃

DprE1-IN-1靶点实验

查看更多实验

实验名称：Antimycobacterial activity against Mycobacterium tuberculosis K12 assessed as reducti... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL5616449

实验名称：Antibacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 5 da... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL3578768

实验名称：Antimycobacterial activity against Mycobacterium smegmatis C2 155 assessed as inhibit... 来源：ChEMBL 靶标：Mycolicibacterium smegmatis External Id：CHEMBL5540933

实验名称：Antimycobacterial activity against autoluminescent Mycobacterium tuberculosis H37Ra a... 来源：ChEMBL 靶标：Mycobacterium tuberculosis External Id：CHEMBL5540934

实验名称：Cytotoxicity against human HepG2 cells assessed as reduction in cell viability 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL5540935

实验名称：Selectivity index, ratio of MIC for Mycobacterium smegmatis overexpressing Mtb DprE1 ... 来源：ChEMBL 靶标：Mycolicibacterium smegmatis External Id：CHEMBL5540936

实验名称：Binding affinity to Mycobacterium tuberculosis DprE1 assessed as conformational chang... 来源：ChEMBL 靶标：Decaprenylphosphoryl-beta-D-ribose oxidase External Id：CHEMBL5540941

实验名称：Binding affinity to Mycobacterium tuberculosis DprE1 assessed as conformational chang... 来源：ChEMBL 靶标：Decaprenylphosphoryl-beta-D-ribose oxidase External Id：CHEMBL5540942

实验名称：Binding affinity to Mycobacterium tuberculosis DprE1 assessed as conformational chang... 来源：ChEMBL 靶标：Decaprenylphosphoryl-beta-D-ribose oxidase External Id：CHEMBL5540943

实验名称：Binding affinity to Mycobacterium tuberculosis DprE1 assessed as conformational chang... 来源：ChEMBL 靶标：Decaprenylphosphoryl-beta-D-ribose oxidase External Id：CHEMBL5540944

共48条，当前第1页，共5页

1

2

3

4

5

DprE1-IN-1英文别名

• DprE1-IN-1
• AZ7371
• N-(2-Hydroxyethyl)-1-[(6-methoxy-5-methyl-4-pyrimidinyl)methyl]-6-methyl-1H-pyrrolo[3,2-b]pyridine-3-carboxamide
• AZ-7371