FINDY

• 常用名: FINDY
• 英文名: FINDY
• CAS号: 1507367-37-4
• 分子量: 347.53
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₇NO₂S₂Si
• 熔点: N/A
• 闪点: N/A

FINDY用途

FINDY是DYRK1A的折叠中间体选择性抑制剂。FINDY可以抑制Ser97自身磷酸化,IC50值为35μM。FINDY可用于神经疾病的研究[1]。

FINDY名称

• 英文名: FINDY

FINDY生物活性

• 描述: FINDY是DYRK1A的折叠中间体选择性抑制剂。FINDY可以抑制Ser97自身磷酸化,IC50值为35μM。FINDY可用于神经疾病的研究[1]。
• 相关类别:
  信号通路 >> 蛋白酪氨酸激酶 >> DYRK
  研究领域 >> 神经疾病
• 靶点实验:

  IC50: 35 μM (Ser97 autophosphorylation)[1]

• 体外研究: FINDY(化合物1)抑制 97系列自磷酸化,国际50值为 35μM[1]
• 参考文献:

  [1]. Yuka Miyazaki, et al. Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A. Eur J Med Chem. 2022 Jan 5;227:113948.

FINDY物理化学性质

• 分子式: C₁₆H₁₇NO₂S₂Si
• 分子量: 347.53

FINDY靶点实验

查看更多实验

实验名称：Inhibition of recombinant human CK1epsilon expressed in Sf9 insect cells incubated fo... 来源：ChEMBL 靶标：Casein kinase I isoform epsilon External Id：CHEMBL5251364

实验名称：Inhibition of recombinant human CDK5/p25 expressed in Sf9 insect cells incubated for ... 来源：ChEMBL 靶标：Cyclin-dependent kinase 5 External Id：CHEMBL5251363

实验名称：Inhibition of recombinant human CLK2 expressed in Sf9 insect cells incubated for 60 m... 来源：ChEMBL 靶标：Dual specificity protein kinase CLK2 External Id：CHEMBL5251366

实验名称：Inhibition of recombinant human CLK1 expressed in Sf9 insect cells incubated for 60 m... 来源：ChEMBL 靶标：Dual specificity protein kinase CLK1 External Id：CHEMBL5251365

实验名称：Inhibition of DYRK1A (unknown origin) 来源：ChEMBL 靶标：Dual specificity tyrosine-phosphorylation-regulated kinase 1A External Id：CHEMBL5254664

实验名称：Inhibition of FYN in HEK293 cells up to 8 uM measured after 4 days by Western blot an... 来源：ChEMBL 靶标：Tyrosine-protein kinase Fyn External Id：CHEMBL5132808

实验名称：Inhibition of MSK1 in HEK293 cells up to 8 uM measured after 4 days by Western blot a... 来源：ChEMBL 靶标：Ribosomal protein S6 kinase alpha-5 External Id：CHEMBL5132809

实验名称：Inhibition of recombinant PKD1 in HEK293 cells at 32 uM using DYRKtide peptide as sub... 来源：ChEMBL 靶标：Polycystin-1 External Id：CHEMBL5132804

实验名称：Inhibition of recombinant ROCK1 in HEK293 cells at 32 uM using DYRKtide peptide as su... 来源：ChEMBL 靶标：Rho-associated protein kinase 1 External Id：CHEMBL5132805

实验名称：Inhibition of HSP90 in HEK293 cells up to 8 uM measured after 4 days by Western blot ... 来源：ChEMBL 靶标：Heat shock protein HSP 90-alpha External Id：CHEMBL5132806

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