亲环蛋白抑制剂1

• 常用名: 亲环蛋白抑制剂1
• 英文名: Cyclophilin inhibitor 1
• CAS号: 1509904-96-4
• 分子量: 593.67
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₁H₃₉N₅O₇
• 熔点: N/A
• 闪点: N/A

亲环蛋白抑制剂1用途

Cyclophilin inhibitor 1 是一种有效、可口服的亲环素 A (cyclophilin A) 抑制剂,Kd 值为 5 nM,具有抗 HCV 活性,对 HCV 2a 的 EC50 值为 98 nM。

亲环蛋白抑制剂1名称

• 中文名: 亲环蛋白抑制剂1
• 英文名: Cyclophilin inhibitor 1

亲环蛋白抑制剂1生物活性

• 描述: Cyclophilin inhibitor 1 是一种有效、可口服的亲环素 A (cyclophilin A) 抑制剂,Kd 值为 5 nM,具有抗 HCV 活性,对 HCV 2a 的 EC50 值为 98 nM。
• 相关类别:
  信号通路 >> 抗感染 >> HCV
  研究领域 >> 感染
• 靶点实验:

  Kd: 5 nM (Cyclophilin A)[1] EC50: 98 nM (HCV 2a)[1]

• 体外研究: 亲环蛋白抑制剂1(化合物3)抑制HCV 2a活性,EC50为98 nM [1]。
• 参考文献:

  [1]. Mackman RL, et al. Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle. J Med Chem. 2018 Nov 8;61(21):9473-9499.

亲环蛋白抑制剂1物理化学性质

• 分子式: C₃₁H₃₉N₅O₇
• 分子量: 593.67
• InChIKey: IVDFPOWAIHEKAG-GOZMEEBJSA-N
• SMILES: CC1NC(=O)C(C(C)C)OC(=O)C2(C=Cc3ccc4ccc(nc4c3)C(C)NC(=O)C3CCCN(N3)C1=O)COCOC2

亲环蛋白抑制剂1靶点实验

查看更多实验

实验名称：Unbound fraction in cell culture medium/buffer dialysis at 2 uM at pH 7.4 by LC/MS/MS... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4157515

实验名称：Unbound fraction in human plasma at 2 uM at pH 7.4 by LC/MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4157516

实验名称：Half life in human plasma at 2 uM up to 4 hrs by LC/MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4157517

实验名称：Half life in dog plasma at 2 uM up to 4 hrs by LC/MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4157518

实验名称：Activation of human full length PXR expressed in human HepG2 cells at 1.5 uM after 48... 来源：ChEMBL 靶标：Nuclear receptor subfamily 1 group I member 2 External Id：CHEMBL4157523

实验名称：Activation of human full length PXR expressed in human HepG2 cells at 15 uM after 48 ... 来源：ChEMBL 靶标：Nuclear receptor subfamily 1 group I member 2 External Id：CHEMBL4157524

实验名称：Half life in rat plasma at 2 uM up to 4 hrs by LC/MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4157519

实验名称：Apparent permeability across apical to basolateral side in human Caco2 cells measured... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4157520

实验名称：Apparent permeability across basolateral to apical side in human Caco2 cells measured... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4157521

实验名称：Lipophilicity, log D of the compound at pH 7.4 after 30 mins by HPLC/UV analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4157522

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