磷酸安他唑啉

• 常用名: 磷酸安他唑啉
• 英文名: Antazoline
• CAS号: 154-68-7
• 分子量: 363.348
• 密度: 0.975 g/mL at 25 °C(lit.)
• 沸点: 235-236 °C(lit.)
• 分子式: C₁₇H₂₂N₃O₄P
• 熔点: 120-122ºC
• 闪点: >230 °F
• 符号: GHS07
• 信号词: Warning

磷酸安他唑啉用途

Antazoline phosphate is an antihistamine with anticholinergic properties used to relieve nasal congestion and the symptoms of allergic conjunctivitis. Antazoline is an ethylenediamine derivative with histamine H1 antagonistic and sedative properties. Antazoline antagonizes histamine H1 receptor and prevents the typical allergic symptoms caused by histamine activities on capillaries, skin, mucous membranes, and gastrointestinal and bronchial smooth muscles.

磷酸安他唑啉名称

• 中文名: N-苄基-4,5-二氢-N-苯基-1H-咪唑-2-甲胺磷酸盐
• 英文名: N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline,phosphoric acid
• 中文别名: 安它唑啉磷酸酯 | 磷酸安他唑啉

磷酸安他唑啉物理化学性质

• 密度: 0.975 g/mL at 25 °C(lit.)
• 沸点: 235-236 °C(lit.)
• 熔点: 120-122ºC
• 分子式: C₁₇H₂₂N₃O₄P
• 分子量: 363.348
• 闪点: >230 °F
• 精确质量: 363.134796
• PSA: 115.20000
• LogP: 1.53070
• InChIKey: DUIGUKRYYAGJAF-UHFFFAOYSA-N
• SMILES: O=P(O)(O)O.c1ccc(CN(CC2=NCCN2)c2ccccc2)cc1
• 蒸汽压: 3.31E-09mmHg at 25°C
• 折射率: n20/D 1.517(lit.)
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:4

  3.氢键受体数量:6

  4.可旋转化学键数量:5

  5.互变异构体数量:无

  6.拓扑分子极性表面积105

  7.重原子数量:25

  8.表面电荷:0

  9.复杂度:364

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:0

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:2

磷酸安他唑啉安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302 + H312 + H332-H315-H319-H335
• 警示性声明: P261-P280-P301 + P312 + P330-P305 + P351 + P338
• 个人防护装备: dust mask type N95 (US);Eyeshields;Gloves
• 危害码 (欧洲): Xn: Harmful;
• 风险声明 (欧洲): R20/21/22
• 安全声明 (欧洲): S26-S36
• 危险品运输编码: NONH for all modes of transport
• WGK德国: 3

磷酸安他唑啉靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：ERK5 transcriptional activity HTS 来源：24565 靶标：N/A External Id：ERK5 transcriptional activity-HTS

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Flow Cytometric HTS Screen for inhibitors of the ABC transporter ABCB6 for Validation... 来源：NMMLSC 靶标：ATP-binding cassette sub-family B member 6, mitochondrial [Homo sapiens] External Id：UNMCMD_ABCB6_1o_ValidationSet

实验名称：Identifying Sarm1 Tir Hydrolase inhibitors through NAD-Glo assay 来源：24386 靶标：N/A External Id：Sarm1 Tir NADase inhibitors screen

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磷酸安他唑啉英文别名

• 1H-Imidazole-2-methanamine, 4,5-dihydro-N-phenyl-N-(phenylmethyl)-, phosphate (1:1)
• Antazoline Phosphate
• Antazoline phosphate (USP)
• UNII-VPR5FPH326
• EINECS 205-831-4
• MFCD00054317
• Antazoline phosphate salt
• 2-(N-Benzylanilinomethyl)-2-imidazoline
• N-Benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline phosphate (1:1)
• 2-(N-PHENYL-N-BENZYL-AMINOMETHYL)-IMIDAZOLINE