pTH (1-31) (human)

• 常用名: pTH (1-31) (human)
• 英文名: pTH (1-31) (human)
• CAS号: 157938-23-3
• 分子量: N/A
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆₂H₂₆₉N₄₉O₄₇S₂
• 熔点: N/A
• 闪点: N/A

pTH (1-31) (human)用途

人PTH-(1-31)是人PTH的1-31片段。人PTH-(1-31)刺激cAMP的释放,也是25-羟基维生素D-1α-羟化酶的较弱刺激因子。人PTH-(1-31)诱导骨形成而不诱导骨吸收。人PTH-(1-31)在骨质疏松症的研究中具有一定的潜力[1][2]。

pTH (1-31) (human)名称

• 英文名: PTH (1-31) (HUMAN)

pTH (1-31) (human)生物活性

• 描述: 人PTH-(1-31)是人PTH的1-31片段。人PTH-(1-31)刺激cAMP的释放,也是25-羟基维生素D-1α-羟化酶的较弱刺激因子。人PTH-(1-31)诱导骨形成而不诱导骨吸收。人PTH-(1-31)在骨质疏松症的研究中具有一定的潜力[1][2]。
• 相关类别:
  信号通路 >> 其他 >> 甲状腺激素受体
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Fraher LJ, et al. Comparison of the biochemical responses to human parathyroid hormone-(1-31)NH2 and hPTH-(1-34) in healthy humans. J Clin Endocrinol Metab. 1999 Aug;84(8):2739-43.

  [2]. K. Henriksen, et al. Evaluation of the efficacy, safety and pharmacokinetic profile of oral recombinant human parathyroid hormone [rhPTH(1-31)NH2] in postmenopausal women with osteoporosis. Bone. 2013, 53 (1): 160-166.

pTH (1-31) (human)物理化学性质

• 分子式: C₁₆₂H₂₆₉N₄₉O₄₇S₂
• 储存条件: -15°C

pTH (1-31) (human)靶点实验

查看更多实验

实验名称：Inhibition in vitro of Phosphodiesterase 1 isolated from guinea pig cardiac ventricle 来源：ChEMBL 靶标：Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B External Id：CHEMBL760660

实验名称：Inhibition in vitro of Phosphodiesterase 3 isolated from guinea pig cardiac ventricle 来源：ChEMBL 靶标：cGMP-inhibited 3',5'-cyclic phosphodiesterase B External Id：CHEMBL761552

实验名称：Inhibition in vitro of Phosphodiesterase 4 activity isolated from guinea pig lung 来源：ChEMBL 靶标：cAMP-specific 3',5'-cyclic phosphodiesterase 4A External Id：CHEMBL767088

实验名称：Inhibition of antigen-induced bronchoconstriction in anesthetized guinea pig at 0.3 m... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL682539

实验名称：Reduced histamine-induced bronchoconstriction in anesthetized guinea pig at 0.3 mg/kg... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL685404

实验名称：Change in heart rate in guinea pigs after 0.3 mg/kg intravenous dose 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL689166

实验名称：Reduced histamine-induced bronchoconstriction in anesthetized guinea pig at 1 mg/kg i... 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL685406

实验名称：Change in heart rate in guinea pigs after 3 mg/kg intravenous dose 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL689168

实验名称：Change in heart rate in guinea pigs after 1 mg/kg intravenous dose 来源：ChEMBL 靶标：Cavia porcellus External Id：CHEMBL689167

实验名称：Selectivity as ratio of IC50 against PDE III to IC50 against PDE IV from guinea pig 来源：ChEMBL 靶标：Phosphodiesterase; PDE3 & PDE4 External Id：CHEMBL840527

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pTH (1-31) (human)英文别名

• PTH (1-31) (HUMAN)