PU-139

• 常用名: PU-139
• 英文名: PU-139
• CAS号: 158093-65-3
• 分子量: 246.260
• 密度: 1.5±0.1 g/cm3
• 沸点: 434.3±51.0 °C at 760 mmHg
• 分子式: C₁₂H₇FN₂OS
• 熔点: N/A
• 闪点: 216.5±30.4 °C

PU-139用途

PU-139是一种有效的非选择性HAT(组蛋白乙酰转移酶)抑制剂,可阻断HATs Gcn5,p300/CBP相关因子(PCAF),CREB蛋白(CBP)和p300；触发细胞培养中不依赖caspase的细胞死亡,阻断SK-N-SH神经母细胞瘤异种移植物在小鼠体内的生长,并协同阿霉素在体内的作用。

PU-139名称

• 英文名: 2-(4-Fluorophenyl)[1,2]thiazolo[5,4-b]pyridin-3(2H)-one

PU-139生物活性

• 描述: PU-139是一种有效的非选择性HAT(组蛋白乙酰转移酶)抑制剂,可阻断HATs Gcn5,p300/CBP相关因子(PCAF),CREB蛋白(CBP)和p300；触发细胞培养中不依赖caspase的细胞死亡,阻断SK-N-SH神经母细胞瘤异种移植物在小鼠体内的生长,并协同阿霉素在体内的作用。
• 参考文献: References 1. Gajer JM, et al. Oncogenesis. 2015 Feb 9;4:e137. 2. Carneiro VC, et al. PLoS Pathog. 2014 May 8;10(5):e1004116. 3. Furdas SD, et al. Bioorg Med Chem. 2011 Jun 15;19(12):3678-89. View Related Products by Target Histone Acetyltransferase (HAT)

PU-139物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 434.3±51.0 °C at 760 mmHg
• 分子式: C₁₂H₇FN₂OS
• 分子量: 246.260
• 闪点: 216.5±30.4 °C
• 精确质量: 246.026306
• LogP: 1.83
• InChIKey: QMCIVCACYJRAAY-UHFFFAOYSA-N
• SMILES: O=c1c2cccnc2sn1-c1ccc(F)cc1
• 蒸汽压: 0.0±1.0 mmHg at 25°C
• 折射率: 1.686
• 储存条件: 2-8°C，干燥，密封

PU-139靶点实验

查看更多实验

实验名称：Inhibition of HAT in human LNCAP cells assessed as decrease in 10 uM SAHA-induced ace... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3626901

实验名称：In vitro inhibition of human recombinant IL-1-beta-induced breakdown of bovine cartil... 来源：ChEMBL 靶标：Bos taurus External Id：CHEMBL654358

实验名称：Inhibition of recombinant human KAT2B catalytic domain using biotinylated histone H3 ... 来源：ChEMBL 靶标：Histone acetyltransferase KAT2B External Id：CHEMBL3626888

实验名称：Inhibition of recombinant human CBP using biotinylated histone H3 (1 to 21 amino acid... 来源：ChEMBL 靶标：CREB-binding protein External Id：CHEMBL3626892

实验名称：Inhibition of recombinant human KAT2A using biotinylated histone H3 (1 to 21 amino ac... 来源：ChEMBL 靶标：Histone acetyltransferase KAT2A External Id：CHEMBL3626891

实验名称：Inhibition of recombinant human KAT2A using biotinylated histone H3 (1 to 21 amino ac... 来源：ChEMBL 靶标：Histone acetyltransferase KAT2A External Id：CHEMBL3626890

实验名称：Inhibition of recombinant human KAT2B catalytic domain using biotinylated histone H3 ... 来源：ChEMBL 靶标：Histone acetyltransferase KAT2B External Id：CHEMBL3626889

实验名称：Inhibition of human MOF at 5 uM 来源：ChEMBL 靶标：Histone acetyltransferase KAT8 External Id：CHEMBL3626896

实验名称：Inhibition of recombinant human p300 using biotinylated histone H3 (1 to 21 amino aci... 来源：ChEMBL 靶标：Histone acetyltransferase p300 External Id：CHEMBL3626895

实验名称：Inhibition of recombinant human p300 using biotinylated histone H3 (1 to 21 amino aci... 来源：ChEMBL 靶标：Histone acetyltransferase p300 External Id：CHEMBL3626894

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PU-139英文别名

• 2-(4-Fluorophenyl)[1,2]thiazolo[5,4-b]pyridin-3(2H)-one