PU-139
Modify Date: 2024-01-13 13:28:17
PU-139 structure
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Common Name | PU-139 | ||
|---|---|---|---|---|
| CAS Number | 158093-65-3 | Molecular Weight | 246.260 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 434.3±51.0 °C at 760 mmHg | |
| Molecular Formula | C12H7FN2OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 216.5±30.4 °C | |
Use of PU-139PU-139 is a potent, unselective HAT (Histone acetyltransferase) inhibitor that blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB protein (CBP) and p300; triggers caspase-independent cell death in cell culture, blocks growth of SK-N-SH neuroblastoma xenografts in mice, and synergizes the effect of doxorubicin in vivo. |
| Name | 2-(4-Fluorophenyl)[1,2]thiazolo[5,4-b]pyridin-3(2H)-one |
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| Synonym | More Synonyms |
| Description | PU-139 is a potent, unselective HAT (Histone acetyltransferase) inhibitor that blocks the HATs Gcn5, p300/CBP-associated factor (PCAF), CREB protein (CBP) and p300; triggers caspase-independent cell death in cell culture, blocks growth of SK-N-SH neuroblastoma xenografts in mice, and synergizes the effect of doxorubicin in vivo. |
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| References | References 1. Gajer JM, et al. Oncogenesis. 2015 Feb 9;4:e137. 2. Carneiro VC, et al. PLoS Pathog. 2014 May 8;10(5):e1004116. 3. Furdas SD, et al. Bioorg Med Chem. 2011 Jun 15;19(12):3678-89. View Related Products by Target Histone Acetyltransferase (HAT) |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 434.3±51.0 °C at 760 mmHg |
| Molecular Formula | C12H7FN2OS |
| Molecular Weight | 246.260 |
| Flash Point | 216.5±30.4 °C |
| Exact Mass | 246.026306 |
| LogP | 1.83 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.686 |
| 2-(4-Fluorophenyl)[1,2]thiazolo[5,4-b]pyridin-3(2H)-one |
| Isothiazolo[5,4-b]pyridin-3(2H)-one, 2-(4-fluorophenyl)- |