GSK2801

• 常用名: GSK2801
• 英文名: GSK 2801
• CAS号: 1619994-68-1
• 分子量: 371.450
• 密度: 1.2±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₀H₂₁NO₄S
• 熔点: N/A
• 闪点: N/A

GSK2801用途

GSK2801是BAZ2A和BAZ2B高效选择性抑制剂，Kd值分别为136nM和257nM。

GSK2801名称

• 中文名: 1-[1-[2-(甲基磺酰基)苯基]-7-丙氧基-3-吲哚嗪基]乙酮
• 英文名: 1-[1-[2-(Methylsulfonyl)phenyl]-7-propoxy-3-indolizinyl]ethanone

GSK2801生物活性

• 描述: GSK2801是BAZ2A和BAZ2B高效选择性抑制剂,Kd值分别为136nM和257nM。
• 相关类别:
  信号通路 >> 表观遗传学 >> 表观遗传读者域
  研究领域 >> 癌症
• 参考文献:

  [1]. Chen P, et al. Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B. J Med Chem. 2015 Apr 6.

GSK2801物理化学性质

• 密度: 1.2±0.1 g/cm3
• 分子式: C₂₀H₂₁NO₄S
• 分子量: 371.450
• 精确质量: 371.119141
• LogP: 2.95
• InChIKey: KHWCPNJRJCNVRI-UHFFFAOYSA-N
• SMILES: CCCOc1ccn2c(C(C)=O)cc(-c3ccccc3S(C)(=O)=O)c2c1
• 外观性状: light yellow solid
• 折射率: 1.596
• 储存条件: -20℃

GSK2801靶点实验

查看更多实验

实验名称：Binding affinity to biotinylated BRD9 (unknown origin) expressed in Escherichia coli ... 来源：ChEMBL 靶标：Bromodomain-containing protein 9 External Id：CHEMBL5713042

实验名称：Binding affinity to recombinant human TAF1L bromodomain-2 assessed as melting tempera... 来源：ChEMBL 靶标：Transcription initiation factor TFIID subunit 1-like External Id：CHEMBL3772747

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Thermal Shift Assay. Domain: start/stop: N44-E168 来源：ChEMBL 靶标：Bromodomain-containing protein 4 External Id：CHEMBL5061265

实验名称：Binding affinity to recombinant human BRD9 assessed as melting temperature shift at 1... 来源：ChEMBL 靶标：Bromodomain-containing protein 9 External Id：CHEMBL3772746

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：Binding affinity to recombinant His6-TEV fused human BAZ2B assessed as melting temper... 来源：ChEMBL 靶标：Bromodomain adjacent to zinc finger domain protein 2B External Id：CHEMBL3772745

实验名称：Binding affinity to biotinylated C-terminal Avi/His-TEV-tagged BAZ2A (unknown origin)... 来源：ChEMBL 靶标：Bromodomain adjacent to zinc finger domain protein 2A External Id：CHEMBL3773108

实验名称：Binding affinity to biotinylated ATAD2 (unknown origin) expressed in Escherichia coli... 来源：ChEMBL 靶标：ATPase family AAA domain-containing protein 2 External Id：CHEMBL3773107

实验名称：Binding affinity to biotinylated ASH1L bromodomain (unknown origin) expressed in Esch... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase ASH1L External Id：CHEMBL3773106

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GSK2801英文别名

• 1-{1-[2-(Methylsulfonyl)phenyl]-7-propoxy-3-indolizinyl}ethanone
• GSK 2801
• GSK2801