GNE-8505

• 常用名: GNE-8505
• 英文名: GNE-8505
• CAS号: 1620573-48-9
• 分子量: 419.44
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₄F₃N₅O
• 熔点: N/A
• 闪点: N/A

GNE-8505用途

GNE-8505 是一种口服有效的双亮氨酸拉链激酶 (DLK) 抑制剂。

GNE-8505名称

• 中文名: GNE-8505
• 英文名: GNE-8505

GNE-8505生物活性

• 描述: GNE-8505 是一种口服有效的双亮氨酸拉链激酶 (DLK) 抑制剂。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> MAPK/ERK信号通路 >> MAP3K
• 靶点实验:

  DLK[1]

• 参考文献:

  [1]. Le Pichon CE, et al. Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease. Sci Transl Med. 2017 Aug 16;9(403). pii: eaag0394.

GNE-8505物理化学性质

• 分子式: C₂₁H₂₄F₃N₅O
• 分子量: 419.44
• InChIKey: IRPVABHDSJVBNZ-RTHVDDQRSA-N
• SMILES: Nc1ncc(-c2cc(C3C4CN(C5COC5)CC43)n(CC3CC3)n2)cc1C(F)(F)F

GNE-8505靶点实验

查看更多实验

实验名称：Binding affinity to 5HT1B receptor (unknown origin) receptor at 10 uM relative to con... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 1B External Id：CHEMBL4120217

实验名称：Binding affinity to 5HT2A receptor (unknown origin) receptor at 10 uM relative to con... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2A External Id：CHEMBL4120218

实验名称：Binding affinity to PDE rolipram binding site (unknown origin) receptor at 10 uM rela... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4120215

实验名称：Binding affinity to 5HT1A receptor (unknown origin) receptor at 10 uM relative to con... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 1A External Id：CHEMBL4120216

实验名称：Binding affinity to recombinant human PPARalpha at 10 uM relative to control 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor alpha External Id：CHEMBL4120213

实验名称：Binding affinity to recombinant human PPARdelta at 10 uM relative to control 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor delta External Id：CHEMBL4120214

实验名称：Binding affinity to (alpha1)2beta1deltaepsilon nAChR (unknown origin) receptor at 10 ... 来源：ChEMBL 靶标：Acetylcholine receptor subunit alpha External Id：CHEMBL4120211

实验名称：Binding affinity to opiod receptor (unknown origin) receptor at 10 uM relative to con... 来源：ChEMBL 靶标：Delta-type opioid receptor External Id：CHEMBL4120212

实验名称：Binding affinity to recombinant full length human ERG at 10 uM relative to control 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL4120225

实验名称：Binding affinity to rat brain KV channel at 10 uM relative to control 来源：ChEMBL 靶标：N/A External Id：CHEMBL4120226

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