GNE-8505

Modify Date: 2025-09-18 18:53:27

GNE-8505 Structure
GNE-8505 structure
Common Name GNE-8505
CAS Number 1620573-48-9 Molecular Weight 419.44
Density N/A Boiling Point N/A
Molecular Formula C21H24F3N5O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of GNE-8505


GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK)[1].

 Names

Name GNE-8505

 GNE-8505 Biological Activity

Description GNE-8505 is an orally available inhibitor of Dual leucine zipper kinase (DLK)[1].
Related Catalog
Target

DLK[1]

References

[1]. Le Pichon CE, et al. Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease. Sci Transl Med. 2017 Aug 16;9(403). pii: eaag0394.

 Chemical & Physical Properties

Molecular Formula C21H24F3N5O
Molecular Weight 419.44
InChIKey IRPVABHDSJVBNZ-RTHVDDQRSA-N
SMILES Nc1ncc(-c2cc(C3C4CN(C5COC5)CC43)n(CC3CC3)n2)cc1C(F)(F)F
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