DLK-IN-1

• 常用名: DLK-IN-1
• 英文名: DLK-IN-1
• CAS号: 1620574-24-4
• 分子量: 423.43
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₂₄F₃N₅O₂
• 熔点: N/A
• 闪点: N/A

DLK-IN-1用途

DLK-IN-1 是双亮氨酸拉链激酶 (DLK, MAP3K12) 的选择性抑制剂,其Ki 值为 3 nM。DLK-IN-1 保持着良好的中枢神经系统穿透能力,并且在脑内剂量过量后依旧耐受性良好,在阿尔兹海默症动物模型中有良好的活性。

DLK-IN-1名称

• 中文名: DLK-IN-1
• 英文名: DLK-IN-1

DLK-IN-1生物活性

• 描述: DLK-IN-1 是双亮氨酸拉链激酶 (DLK, MAP3K12) 的选择性抑制剂,其Ki 值为 3 nM。DLK-IN-1 保持着良好的中枢神经系统穿透能力,并且在脑内剂量过量后依旧耐受性良好,在阿尔兹海默症动物模型中有良好的活性。
• 相关类别:
  研究领域 >> 神经疾病
  信号通路 >> MAPK/ERK信号通路 >> MAP3K
• 靶点实验:

  Ki: 3 nM (DLK)[1].

• 参考文献:

  [1]. Patel S, et al. Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease. J Med Chem. 2017 Oct 12;60(19):8083-8102.

DLK-IN-1物理化学性质

• 分子式: C₂₀H₂₄F₃N₅O₂
• 分子量: 423.43
• InChIKey: UHEFRVBGJORHNV-UUVAVEHKSA-N
• SMILES: CC(C)n1nc(-c2cnc(N)c(OC(F)(F)F)c2)cc1C1C2CN(C3COC3)CC21
• 储存条件: 2-8℃

DLK-IN-1靶点实验

查看更多实验

实验名称：Binding affinity to 5HT1B receptor (unknown origin) receptor at 10 uM relative to con... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 1B External Id：CHEMBL4120217

实验名称：Binding affinity to 5HT2A receptor (unknown origin) receptor at 10 uM relative to con... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2A External Id：CHEMBL4120218

实验名称：Binding affinity to PDE rolipram binding site (unknown origin) receptor at 10 uM rela... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4120215

实验名称：Binding affinity to 5HT1A receptor (unknown origin) receptor at 10 uM relative to con... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 1A External Id：CHEMBL4120216

实验名称：Binding affinity to recombinant human PPARalpha at 10 uM relative to control 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor alpha External Id：CHEMBL4120213

实验名称：Binding affinity to recombinant human PPARdelta at 10 uM relative to control 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor delta External Id：CHEMBL4120214

实验名称：Binding affinity to (alpha1)2beta1deltaepsilon nAChR (unknown origin) receptor at 10 ... 来源：ChEMBL 靶标：Acetylcholine receptor subunit alpha External Id：CHEMBL4120211

实验名称：Binding affinity to opiod receptor (unknown origin) receptor at 10 uM relative to con... 来源：ChEMBL 靶标：Delta-type opioid receptor External Id：CHEMBL4120212

实验名称：Binding affinity to recombinant full length human ERG at 10 uM relative to control 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL4120225

实验名称：Binding affinity to rat brain KV channel at 10 uM relative to control 来源：ChEMBL 靶标：N/A External Id：CHEMBL4120226

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