DLK-IN-1

Modify Date: 2024-02-04 22:37:31

DLK-IN-1 structure	Common Name	DLK-IN-1
	CAS Number	1620574-24-4	Molecular Weight	423.43
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₂₄F₃N₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of DLK-IN-1

DLK-IN-1 is a selective inhibitor of dual leucine zipper kinase (DLK, MAP3K12), with a Ki of 3 nM. DLK-IN-1 retains excellent CNS penetration and is well tolerated following multiple days of dosing at concentrations that exceed those required for DLK inhibition in the brain. DLK-IN-1 has activity in a model of Alzheimer’s Disease.

Name	DLK-IN-1

Description	DLK-IN-1 is a selective inhibitor of dual leucine zipper kinase (DLK, MAP3K12), with a Ki of 3 nM. DLK-IN-1 retains excellent CNS penetration and is well tolerated following multiple days of dosing at concentrations that exceed those required for DLK inhibition in the brain. DLK-IN-1 has activity in a model of Alzheimer’s Disease.
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> MAPK/ERK Pathway >> MAP3K
Target	Ki: 3 nM (DLK)[1].
References	[1]. Patel S, et al. Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease. J Med Chem. 2017 Oct 12;60(19):8083-8102.

Molecular Formula	C₂₀H₂₄F₃N₅O₂
Molecular Weight	423.43
Storage condition	2-8℃

DC Chemicals Limited
China
Product Name: DLK-IN-14
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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