LY3202626

• 常用名: LY3202626
• 英文名: LY3202626
• CAS号: 1628690-73-2
• 分子量: 498.508
• 密度: 1.6±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₂H₂₀F₂N₈O₂S
• 熔点: N/A
• 闪点: N/A

LY3202626用途

LY3202626是一种小分子非选择性BACE1抑制剂,可引起CSF和血浆aβ浓度的剂量依赖性降低,显示出治疗阿尔茨海默病的潜力。阿尔茨海默病2期临床

LY3202626名称

• 英文名: N-{3-[(4aR,7aS)-2-Amino-6-(5-fluoro-2-pyrimidinyl)-4a,5,6,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a(4H)-yl]-4-fluorophenyl}-5-methoxy-2-pyrazinecarboxamide

LY3202626生物活性

• 描述: LY3202626是一种小分子非选择性BACE1抑制剂,可引起CSF和血浆aβ浓度的剂量依赖性降低,显示出治疗阿尔茨海默病的潜力。阿尔茨海默病2期临床
• 参考文献: References View Related Products by Target Beta-secretase (BACE) Alzheimer Disease

LY3202626物理化学性质

• 密度: 1.6±0.1 g/cm3
• 分子式: C₂₂H₂₀F₂N₈O₂S
• 分子量: 498.508
• 精确质量: 498.139801
• LogP: 3.08
• InChIKey: VQSRKMNBWMHJKY-YTEVENLXSA-N
• SMILES: COc1cnc(C(=O)Nc2ccc(F)c(C34CN(c5ncc(F)cn5)CC3CSC(N)=N4)c2)cn1
• 折射率: 1.750

LY3202626靶点实验

查看更多实验

实验名称：Antialzheimer activity in human CSF assessed as reduction in amyloid-beta 1-42 level ... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL5034218

实验名称：Antialzheimer activity in human CSF assessed as reduction in amyloid-beta 1-40 level ... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL5034217

实验名称：Antialzheimer activity in human CSF assessed as reduction in amyloid-beta 1-40 level ... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL5034216

实验名称：Antialzheimer activity in human CSF assessed as reduction in amyloid-beta 1-40 level ... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL5034215

实验名称：Ratio of free drug concentration in CSF to plasma of dog 来源：ChEMBL 靶标：N/A External Id：CHEMBL5034222

实验名称：Unbound fraction in dog plasma 来源：ChEMBL 靶标：N/A External Id：CHEMBL5034221

实验名称：Antialzheimer activity in human CSF assessed as reduction in amyloid-beta 1-42 level ... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL5034220

实验名称：Antialzheimer activity in human CSF assessed as reduction in amyloid-beta 1-42 level ... 来源：ChEMBL 靶标：Homo sapiens External Id：CHEMBL5034219

实验名称：Unbound fraction in mouse brain 来源：ChEMBL 靶标：N/A External Id：CHEMBL5034210

实验名称：Unbound fraction in mouse plasma 来源：ChEMBL 靶标：N/A External Id：CHEMBL5034209

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LY3202626英文别名

• N-{3-[(4aR,7aS)-2-Amino-6-(5-fluoro-2-pyrimidinyl)-4a,5,6,7-tetrahydropyrrolo[3,4-d][1,3]thiazin-7a(4H)-yl]-4-fluorophenyl}-5-methoxy-2-pyrazinecarboxamide