BMS-191095

• 常用名: BMS-191095
• 英文名: BMS-191095
• CAS号: 166095-21-2
• 分子量: 408.88100
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₁ClN₄O₂
• 熔点: N/A
• 闪点: N/A

BMS-191095用途

BMS-191095是线粒体ATP敏感性(mitoKATP)的钾离子通道活化剂。

BMS-191095名称

• 中文名: BMS-191095
• 英文名: (3R,4S)-4-[(4-Chlorophenyl)(1H-imidazol-2-ylmethyl)amino]-3-hydro xy-2,2-dimethyl-6-chromanecarbonitrile

BMS-191095生物活性

• 描述: BMS-191095是线粒体ATP敏感性(mitoKATP)的钾离子通道活化剂。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钾通道
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Katakam PV, et al. Diversity of mitochondria-dependent dilator mechanisms in vascular smooth muscle of cerebral arteries from normal and insulin-resistant rats. Am J Physiol Heart Circ Physiol. 2014 Aug 15;307(4):H493-503.

BMS-191095物理化学性质

• 分子式: C₂₂H₂₁ClN₄O₂
• 分子量: 408.88100
• 精确质量: 408.13500
• PSA: 85.17000
• LogP: 4.21458
• InChIKey: SMIKIPXIDLITMP-LEWJYISDSA-N
• SMILES: CC1(C)Oc2ccc(C#N)cc2C(N(Cc2ncc[nH]2)c2ccc(Cl)cc2)C1O
• 储存条件: 2-8℃

BMS-191095靶点实验

查看更多实验

实验名称：Cardioprotective effect in Langendorff perfused isolated rat hearts assessed as reduc... 来源：ChEMBL 靶标：Heart External Id：CHEMBL1043123

实验名称：Vasorelaxant potency determined by measurement of IC50 value for relaxation of rat ao... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL796889

实验名称：The inhibitory concentration (IC50) for vasorelaxation on rat aorta 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL784340

实验名称：In vitro relaxation of rat aorta precontracted with methoxamine. 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL785073

实验名称：Pharmacokinetic parameter Tmax following oral administration of 30 umol/kg 来源：ChEMBL 靶标：N/A External Id：CHEMBL629455

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：Apparent terminal elimination half life in rats 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL633934

实验名称：Ratio of the EC25 value for time to contracture and IC50 value for vasorelaxant poten... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL852502

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

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BMS-191095英文别名

• BMS-191095