UK-2A

• 常用名: UK-2A
• 英文名: UK-2A
• CAS号: 167173-85-5
• 分子量: 514.52400
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₃₀N₂O₉
• 熔点: N/A
• 闪点: N/A

UK-2A用途

UK-2A(抗生素UK2A)是一种有效的抗真菌抗生素。UK-2A显示抗真菌活性[1][2]。

UK-2A名称

• 英文名: (3S,6S,7R,8R)-8-benzyl-3-{[(3-hydroxy-4-methoxypyridin-2-yl)carbonyl]amino}-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl2-methylpropanoate

UK-2A生物活性

• 描述: UK-2A(抗生素UK2A)是一种有效的抗真菌抗生素。UK-2A显示抗真菌活性[1][2]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 真菌
• 体外研究: UK-2A(0-100µg/mL；24、48、120小时)显示出针抗真菌活性,对 粘菌R.mucilaginosa IFO 0001在 24、48、120 小时的 麦克风值分别为 1.56、>100、>100µg/mL[2]
• 参考文献:

  [1]. Ueki M, et al. UK-2A, B, C and D, novel antifungal antibiotics from Streptomyces sp. 517-02. I. Fermentation, isolation, and biological properties. J Antibiot (Tokyo). 1996 Jul;49(7):639-43.

  [2]. Tani K, et al. UK-2A, B, C, and D, novel antifungal antibiotics from Streptomyces sp. 517-02 VII. Membrane injury induced by C9-UK-2A, a derivative of UK-2A, in Rhodotorula mucilaginosa IFO 0001. J Antibiot (Tokyo). 2002 Mar;55(3):315-21.

UK-2A物理化学性质

• 分子式: C₂₆H₃₀N₂O₉
• 分子量: 514.52400
• 精确质量: 514.19500
• PSA: 150.35000
• LogP: 2.20030
• InChIKey: MLGCATYQZVMGBG-PBWVOLNLSA-N
• SMILES: COc1ccnc(C(=O)NC2COC(=O)C(Cc3ccccc3)C(OC(=O)C(C)C)C(C)OC2=O)c1O

UK-2A靶点实验

查看更多实验

实验名称：Cytotoxicity against rat RBL2H3 cells assessed as inhibition of cell proliferation up... 来源：ChEMBL 靶标：RBL-2H3 External Id：CHEMBL4270211

实验名称：Antifungal activity against Rhodotorula mucilaginosa IFO 0001 来源：ChEMBL 靶标：Rhodotorula mucilaginosa External Id：CHEMBL854288

实验名称：Anti-inflammatory activity in DNP-IgE-stimulated rat RBL2H3 cells assessed as reducti... 来源：ChEMBL 靶标：RBL-2H3 External Id：CHEMBL4270212

实验名称：Zone of inhibition for Saccharomyces cerevisiae IFO 0203 at 0.25 ug/disc by conventio... 来源：ChEMBL 靶标：Saccharomyces cerevisiae External Id：CHEMBL838270

实验名称：Zone of inhibition for Saccharomyces cerevisiae IFO 0203 at 0.05 ug/disc by conventio... 来源：ChEMBL 靶标：Saccharomyces cerevisiae External Id：CHEMBL838269

实验名称：Anti-inflammatory activity in DNP-IgE-stimulated rat RBL2H3 cells assessed as reducti... 来源：ChEMBL 靶标：RBL-2H3 External Id：CHEMBL4270208

实验名称：Zone of inhibition for Saccharomyces cerevisiae IFO 0203 at 0.025 ug/disc by conventi... 来源：ChEMBL 靶标：Saccharomyces cerevisiae External Id：CHEMBL838275

实验名称：Respiratory inhibition in bovine heart submitochondrial particles 来源：ChEMBL 靶标：Bos taurus External Id：CHEMBL854289

实验名称：Zone of inhibition for Saccharomyces cerevisiae IFO 0203 at 0.125 ug/disc by conventi... 来源：ChEMBL 靶标：Saccharomyces cerevisiae External Id：CHEMBL825429

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UK-2A英文别名

• UK-2A
• (3S,6S,7R,8R)-8-benzyl-3-(3-hydroxy-4-methoxypicolinamido)-6-methyl-4,9-dioxo-1,5-dioxonan-7-yl isobutyrate
• Isobutyric acid (3S,6S,7R,8R)-8-benzyl-3-[(3-hydroxy-4-methoxy-pyridine-2-carbonyl)-amino]-6-methyl-4,9-dioxo-[1,5]dioxonan-7-yl ester
• (3S,6S,7R,8R)-8-benzyl-3-(3-hydroxy-4-methoxypicolinamido)-6-methyl-4,9-dioxo-1,5-di-oxonan-7-yl isobutyrate