SC58451

• 常用名: SC58451
• 英文名: SC58451
• CAS号: 168433-84-9
• 分子量: 342.42700
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₉FO₂S
• 熔点: N/A
• 闪点: N/A

SC58451用途

SC58451 是一个强效的,有选择性的 COX-2 抑制剂。

SC58451名称

• 中文名: SC58451
• 英文名: sc-58451

SC58451生物活性

• 描述: SC58451 是一个强效的,有选择性的 COX-2 抑制剂。
• 相关类别:
  研究领域 >> 炎症/免疫
• 靶点实验:

  COX-2

• 参考文献:

  [1]. Li JJ, et al. Novel terphenyls as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents. J Med Chem. 1996 Apr 26;39(9):1846-56.

SC58451物理化学性质

• 分子式: C₂₀H₁₉FO₂S
• 分子量: 342.42700
• 精确质量: 342.10900
• PSA: 42.52000
• LogP: 5.79480
• InChIKey: VZCIAZMKVAJRCL-UHFFFAOYSA-N
• SMILES: CS(=O)(=O)c1ccc(C2=C(c3ccc(F)cc3)CC3(CC3)C2)cc1
• 储存条件: 2-8℃

SC58451靶点实验

查看更多实验

实验名称：Selectivity ratio against COX-1 and COX-2 binding 来源：ChEMBL 靶标：Prostaglandin G/H synthase 1 External Id：CHEMBL849005

实验名称：Percentage of inhibition against adjuvant induced arthritis at 1 mpk 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL790834

实验名称：Inhibition of PGE-2 production by arachidonic acid-stimulated CHO cells expressing hu... 来源：ChEMBL 靶标：Prostaglandin G/H synthase 2 External Id：CHEMBL763346

实验名称：Anti inflammatory activity determined in adjuvant-induced arthritis assay 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL787780

实验名称：Half life in rat 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL631510

实验名称：Selectivity (COX-1/COX-2) was determined 来源：ChEMBL 靶标：Prostaglandin G/H synthase 1 External Id：CHEMBL850706

实验名称：Partition coefficient (logP) 来源：ChEMBL 靶标：N/A External Id：CHEMBL632389

实验名称：Inhibition of Carrageenan-induced foot-pad oedema in rat following 30 mg/kg administr... 来源：ChEMBL 靶标：Prostaglandin G/H synthase 1 External Id：CHEMBL787237

实验名称：Compound was evaluated for the effective dose in rat adjuvant-induced arthritis model... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL784840

实验名称：Compound was tested in vivo for percentage efficacy in the rat paw edema assay upon o... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL787788

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SC58451英文别名

• 5-(4-fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro [2.4]hept-5-ene
• 5-(4-fluorophenyl)-6-[4-(methylsulfonyl)phenyl]spiro[2.4]hept-5-ene
• 5-(4-fluorophenyl)-6-[4-(methylsulfonyl)phenyl]-spiro[2.4]hept-5-ene
• 5-(4-fluorophenyl)-6-(4-(methylsulfonyl)phenyl)spiro[2.4]hept-5-ene
• 5-(4-fluorophenyl)-6-[4-(methylsulfonyl)phenyl]spiro [2.4]hept-5-ene
• 5-(4-fluorophenyl)-6-[4-(methylsulfonyl)phenyl] spiro[2.4]hept-5-ene
• 5-(4-Fluoro-phenyl)-6-(4-methanesulfonyl-phenyl)-spiro[2.4]hept-5-ene
• SC58451