2’-Deoxy-N6-cyclopentyladenosine

• 常用名: 2’-Deoxy-N6-cyclopentyladenosine
• 英文名: 2’-Deoxy-N6-cyclopentyladenosine
• CAS号: 170711-45-2
• 分子量: 319.36
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₅H₂₁N₅O₃
• 熔点: N/A
• 闪点: N/A

2’-Deoxy-N6-cyclopentyladenosine用途

2'-脱氧-N6-环戊基糖苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

2’-Deoxy-N6-cyclopentyladenosine名称

• 英文名: (2R,3S,5R)-5-[6-(cyclopentylamino)purin-9-yl]-2-(hydroxymethyl)oxolan-3-ol

2’-Deoxy-N6-cyclopentyladenosine生物活性

• 描述: 2'-脱氧-N6-环戊基糖苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
• 参考文献:

  [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

2’-Deoxy-N6-cyclopentyladenosine物理化学性质

• 分子式: C₁₅H₂₁N₅O₃
• 分子量: 319.36
• 精确质量: 319.16400
• PSA: 105.32000
• LogP: 0.89450
• InChIKey: VBGZTYNASPQLSI-QJPTWQEYSA-N
• SMILES: OCC1OC(n2cnc3c(NC4CCCC4)ncnc32)CC1O

2’-Deoxy-N6-cyclopentyladenosine靶点实验

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实验名称：Affinity for the Adenosine A1 receptor in the absence of GTP (A1-GTP) by using [3H]DP... 来源：ChEMBL 靶标：Adenosine receptor A1 External Id：CHEMBL641715

实验名称：Affinity for the Adenosine A1 receptor in the presence of GTP (A1+GTP) by using [3H]-... 来源：ChEMBL 靶标：Adenosine receptor A1 External Id：CHEMBL641716

实验名称：Percentage of apoptotic cells in human peripheral blood mononuclear cells after 72 ho... 来源：ChEMBL 靶标：N/A External Id：CHEMBL760555

实验名称：% of the receptors in the high affinity state 来源：ChEMBL 靶标：Adenosine receptors; A1 & A2a External Id：CHEMBL845910

实验名称：Binding affinity against Adenosine A2A receptor by using [3H]CGS-21680 as radioligand 来源：ChEMBL 靶标：Adenosine receptor A2a External Id：CHEMBL647738

实验名称：Percent relative intrinsic activity compared to CCPA 来源：ChEMBL 靶标：Adenosine receptor A1 External Id：CHEMBL794201

实验名称：Binding affinity for adenosine A1 receptor, was assessed from the ability to displace... 来源：ChEMBL 靶标：Adenosine receptor A1 External Id：CHEMBL637713

实验名称：Binding affinity for adenosine A1 receptor, was assessed from the ability to displace... 来源：ChEMBL 靶标：Adenosine receptor A1 External Id：CHEMBL637714

实验名称：Stimulation of [35S]GTP-gamma-S, binding to rat brain membranes by adenosine A1 recep... 来源：ChEMBL 靶标：Adenosine receptor A1 External Id：CHEMBL823612

实验名称：Binding affinity for adenosine A1 receptor, was assessed from the ability to displace... 来源：ChEMBL 靶标：Adenosine receptor A1 External Id：CHEMBL648315

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2’-Deoxy-N6-cyclopentyladenosine英文别名

• Adenosine,N-cyclopentyl-2'-deoxy