ARTD10/PARP10-IN-2

• 常用名: ARTD10/PARP10-IN-2
• 英文名: ARTD10/PARP10-IN-2
• CAS号: 1708103-69-8
• 分子量: 247.25
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₂H₁₃N₃O₃
• 熔点: N/A
• 闪点: N/A

ARTD10/PARP10-IN-2用途

ARTD10/PARTP10-IN-2(化合物19)是一种有效的非选择性PARP抑制剂,靶向单ADP核糖转移酶ARTD10/PARP10和聚(ADP核糖)聚合酶-1 ARTD1/PARP1,IC50分别为2.0μM和9.7μM[1]。

ARTD10/PARP10-IN-2名称

• 英文名: ARTD10/PARP10-IN-2

ARTD10/PARP10-IN-2生物活性

• 描述: ARTD10/PARTP10-IN-2(化合物19)是一种有效的非选择性PARP抑制剂,靶向单ADP核糖转移酶ARTD10/PARP10和聚(ADP核糖)聚合酶-1 ARTD1/PARP1,IC50分别为2.0μM和9.7μM[1]。
• 相关类别:
  信号通路 >> 表观遗传学 >> PARP
  研究领域 >> 炎症/免疫
  信号通路 >> 细胞周期/DNA损伤 >> PARP
• 靶点实验:

  ARTD1/PARP1:9.7 μM (IC50)

  ARTD10/PARP10:2.0 μM (IC50)

  ARTD8/PARP14:>20 μM (IC50)

  ARTD7/PARP15:>20 μM (IC50)

• 参考文献:

  [1]. Ekblad T, et al. Towards small molecule inhibitors of mono-ADP-ribosyltransferases. Eur J Med Chem. 2015 May 5;95:546-51.

ARTD10/PARP10-IN-2物理化学性质

• 分子式: C₁₂H₁₃N₃O₃
• 分子量: 247.25

ARTD10/PARP10-IN-2靶点实验

查看更多实验

实验名称：Inhibition of hexahistidine-tagged full length human recombinant ARTD1 expressed in E... 来源：ChEMBL 靶标：Poly [ADP-ribose] polymerase 1 External Id：CHEMBL3420116

实验名称：Inhibition of hexahistidine-tagged human recombinant ARTD8 catalytic domain (1611 to ... 来源：ChEMBL 靶标：Protein mono-ADP-ribosyltransferase PARP14 External Id：CHEMBL3420114

实验名称：Inhibition of hexahistidine-tagged human recombinant ARTD7 catalytic domain (459 to 6... 来源：ChEMBL 靶标：Protein mono-ADP-ribosyltransferase PARP15 External Id：CHEMBL3420115

实验名称：Inhibition of hexahistidine-tagged full length human recombinant ARTD10 expressed in ... 来源：ChEMBL 靶标：Protein mono-ADP-ribosyltransferase PARP10 External Id：CHEMBL3420113

共4条，当前第1页，共1页

1