N6-iso-Propyladenosine

• 常用名: N6-iso-Propyladenosine
• 英文名: N6-iso-Propyladenosine
• CAS号: 17270-23-4
• 分子量: 309.32
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₃H₁₉N₅O₄
• 熔点: N/A
• 闪点: N/A

N6-iso-Propyladenosine用途

N6-异丙基腺苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

N6-iso-Propyladenosine名称

• 英文名: N6-Isopropyladenosine

N6-iso-Propyladenosine生物活性

• 描述: N6-异丙基腺苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
• 参考文献:

  [1]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500.

  [2]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

N6-iso-Propyladenosine物理化学性质

• 分子式: C₁₃H₁₉N₅O₄
• 分子量: 309.32
• 精确质量: 309.14400
• PSA: 125.55000
• InChIKey: LILZBBGKOTULGC-QYVSTXNMSA-N
• SMILES: CC(C)Nc1ncnc2c1ncn2C1OC(CO)C(O)C1O

N6-iso-Propyladenosine靶点实验

查看更多实验

实验名称：Concentration required for 50% growth inhibition of the following cell lines human fi... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL697241

实验名称：HPLC capacity factor (k') 来源：ChEMBL 靶标：N/A External Id：CHEMBL638343

实验名称：Concentration required for 50% growth inhibition of the following cell lines human bu... 来源：ChEMBL 靶标：Burkitts lymphoma cell External Id：CHEMBL697267

实验名称：Binding affinity against adenosine A1 receptor using N6-[3H]cyclohexyladenosine as ra... 来源：ChEMBL 靶标：Adenosine receptor A1 External Id：CHEMBL640353

实验名称：Antitumor activity against mouse leukemia, L-1210(DBA/2 Ha Mice) mean life span (days... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL741882

实验名称：Antitumor activity against slow growing spontaneous mammary tumors in the DBA/2 Ha-DD... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL741883

实验名称：Binding affinity to ENT1 transporter 来源：ChEMBL 靶标：Equilibrative nucleoside transporter 1 External Id：CHEMBL936364

实验名称：Antitumor activity against mouse leukemia, L-1210(DBA/2 Ha Mice) mean life span ( day... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL741724

实验名称：Inhibition of Trypanosoma brucei phosphoglycerate kinase (PGK); inactive at 4 mM 来源：ChEMBL 靶标：Phosphoglycerate kinase 1 External Id：CHEMBL766247

实验名称：Concentration required for 50% growth inhibition of the following cell lines human bl... 来源：ChEMBL 靶标：NON-PROTEIN TARGET External Id：CHEMBL872447

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N6-iso-Propyladenosine英文别名

• N6-isopropyladenosine
• N6-isopropyladenosine
• N6-isopropyl-adenosine
• 6-(1-Methyl)ethylamino-9-(β-D-ribofuranosyl)purine
• 6-Isopropylamino-purin ribosid