Carboxycinnamic acid bishydroxamide

• 常用名: Carboxycinnamic acid bishydroxamide
• 英文名: Carboxycinnamic acid bishydroxamide
• CAS号: 174664-65-4
• 分子量: 222.20
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₀H₁₀N₂O₄
• 熔点: N/A
• 闪点: N/A

Carboxycinnamic acid bishydroxamide用途

间羧基肉桂酸双羟肟是一种有效的HDAC抑制剂,HDAC1和HDAC3在体外的ID50值分别为10和70 nM【1】。间羧基肉桂酸双羟肟也可诱导细胞凋亡并抑制肿瘤生长[2]。

Carboxycinnamic acid bishydroxamide名称

• 英文名: m-Carboxycinnamic Acid Bishydroxamide

Carboxycinnamic acid bishydroxamide生物活性

• 描述: 间羧基肉桂酸双羟肟是一种有效的HDAC抑制剂,HDAC1和HDAC3在体外的ID50值分别为10和70 nM【1】。间羧基肉桂酸双羟肟也可诱导细胞凋亡并抑制肿瘤生长[2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> HDAC
  信号通路 >> 表观遗传学 >> HDAC
• 参考文献:

  [1]. Richon VM, et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3003-7.

  [2]. Glick RD, et al. Hybrid polar histone deacetylase inhibitor induces apoptosis and CD95/CD95 ligand expression in human neuroblastoma. Cancer Res. 1999 Sep 1;59(17):4392-9.

Carboxycinnamic acid bishydroxamide物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₁₀H₁₀N₂O₄
• 分子量: 222.20
• 精确质量: 222.064056
• PSA: 98.66000
• LogP: -0.09
• InChIKey: OYKBQNOPCSXWBL-SNAWJCMRSA-N
• SMILES: O=C(C=Cc1cccc(C(=O)NO)c1)NO
• 折射率: 1.668

Carboxycinnamic acid bishydroxamide靶点实验

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实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：Inhibition of HDAC3 (unknown origin) 来源：ChEMBL 靶标：Histone deacetylase 3 External Id：CHEMBL4035203

实验名称：Inhibition of HDAC1 (unknown origin) 来源：ChEMBL 靶标：Histone deacetylase 1 External Id：CHEMBL4035201

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

实验名称：Discovering small molecule activators of G protein-gated inwardly-rectifying potassiu... 来源：15621 靶标：G protein-activated inward rectifier potassium channel 2 External Id：VANDERBILT_HTS_GIRK2_MPD

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Carboxycinnamic acid bishydroxamide英文别名

• N-hydroxy-3-[3-(hydroxyamino)-3-oxoprop-1-enyl]benzamide
• N-Hydroxy-3-[(1E)-3-(hydroxyamino)-3-oxo-1-propen-1-yl]benzamide