BPIQ-I

• 常用名: BPIQ-I
• 英文名: BPIQ-I
• CAS号: 174709-30-9
• 分子量: 354.20400
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₂BrN₅
• 熔点: N/A
• 闪点: N/A

BPIQ-I用途

BPIQ-I(PD 159121)是一种有效的ATP竞争性EGFR酪氨酸激酶抑制剂。。BPIQ-I显示出抗增殖活性[1][2]。

BPIQ-I名称

• 英文名: N-(3-bromophenyl)-3-methylimidazo[4,5-g]quinazolin-8-amine

BPIQ-I生物活性

• 描述: BPIQ-I(PD 159121)是一种有效的ATP竞争性EGFR酪氨酸激酶抑制剂。。BPIQ-I显示出抗增殖活性[1][2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> JAK/STAT信号通路 >> EGFR
  信号通路 >> 蛋白酪氨酸激酶 >> EGFR
• 体外研究: BPIQ-I(0-50µM；3天)具有抗增殖活性,对 A-431,MDA-MB-468,U-87,SKOV-3,MDAMB-231细胞的 第50周值分别为 >50、30、>50、6.5、>50µM[1]。BPIQ-I(10 nM)通过与 三磷酸腺苷竞争来阻断 erbB RTK从而消除 二氧化碳敏感性[2]。 细胞活力测定[1]细胞系：A-431、MDA-MB-468、U-87、SKOV-3、MDAMB-231细胞浓度：0-50µM培养时间：3天结果：A-431,MDA-MB-468、U-87,SKOV-3和MDAMB-221细胞的EC50分别为>50、30、>50、6.5和>50µM,抑制细胞生长。
• 参考文献:

  [1]. Rae JM, et al. Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitors. Breast Cancer Res Treat. 2004 Jan;83(2):99-107.

  [2]. Zhou Y, et al. Role of a tyrosine kinase in the CO2-induced stimulation of HCO3- reabsorption by rabbit S2 proximal tubules. Am J Physiol Renal Physiol. 2006 Aug;291(2):F358-67.

BPIQ-I物理化学性质

• 分子式: C₁₆H₁₂BrN₅
• 分子量: 354.20400
• 精确质量: 353.02800
• PSA: 55.63000
• LogP: 4.09560
• InChIKey: YAMAGACQNDAKFB-UHFFFAOYSA-N
• SMILES: Cn1cnc2cc3c(Nc4cccc(Br)c4)ncnc3cc21

BPIQ-I靶点实验

查看更多实验

实验名称：Millipore: Percentage of residual kinase activity of PRKAA2 at 10uM relative to contr... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219380

实验名称：Millipore: Percentage of residual kinase activity of NUAK1 at 1uM relative to control... 来源：ChEMBL 靶标：NUAK family SNF1-like kinase 1 External Id：CHEMBL2219381

实验名称：Millipore: Percentage of residual kinase activity of PRKAA1 at 10uM relative to contr... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219378

实验名称：Millipore: Percentage of residual kinase activity of PRKAA2 at 1uM relative to contro... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219379

实验名称：Millipore: Percentage of residual kinase activity of MAP3K5 at 10uM relative to contr... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase 5 External Id：CHEMBL2218943

实验名称：Millipore: Percentage of residual kinase activity of ABL1 at 1uM relative to control.... 来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1 External Id：CHEMBL2218944

实验名称：Millipore: Percentage of residual kinase activity of NUAK1 at 10uM relative to contro... 来源：ChEMBL 靶标：NUAK family SNF1-like kinase 1 External Id：CHEMBL2219382

实验名称：Millipore: Percentage of residual kinase activity of MAP3K5 at 1uM relative to contro... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase 5 External Id：CHEMBL2219383

实验名称：Millipore: Percentage of residual kinase activity of TNK2 at 10uM relative to control... 来源：ChEMBL 靶标：Activated CDC42 kinase 1 External Id：CHEMBL2219372

实验名称：Millipore: Percentage of residual kinase activity of ALK at 1uM relative to control. ... 来源：ChEMBL 靶标：ALK tyrosine kinase receptor External Id：CHEMBL2219373

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BPIQ-I英文别名

• HMS3229C05
• 8-[(3-Bromophenyl)amino]-3-methyl-3H-imidazo[4,5-g]-quinazoline
• Imidazoquinazoline deriv. 12
• IN1402
• bpiq-i