缬更昔洛韦

• 常用名: 缬更昔洛韦
• 英文名: Valganciclovir
• CAS号: 175865-60-8
• 分子量: 354.362
• 密度: 1.6±0.1 g/cm3
• 沸点: 629.1±65.0 °C at 760 mmHg
• 分子式: C₁₄H₂₂N₆O₅
• 熔点: N/A
• 闪点: 334.3±34.3 °C

缬更昔洛韦用途

Valganciclovir是ganciclovir的原药，具有抗巨细胞病毒CMV感染的活性。

缬更昔洛韦名称

• 中文名: 缬更昔洛韦
• 英文名: valganciclovir
• 中文别名: (S)-2-氨基-3-甲基丁酸 (R,S)-2-[(2-氨基-6-氧代-1,6-二氢-9H-嘌呤-9-基)甲氧基]-3-羟基丙酯

缬更昔洛韦生物活性

• 描述: Valganciclovir是ganciclovir的原药,具有抗巨细胞病毒CMV感染的活性。
• 相关类别:
  信号通路 >> 抗感染 >> CMV
  研究领域 >> 感染
• 参考文献:

  [1]. Sugawara M, et al. Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2. J Pharm Sci. 2000 Jun;89(6):781-9.

  [2]. Chawla JS, et al. Oral valganciclovir versus ganciclovir as delayed pre-emptive therapy for patients after allogeneic hematopoietic stem cell transplant: a pilot trial (04-0274) and review of the literature. Transpl Infect Dis. 2012 Jun;14(3):259-67.

  [3]. O'Brien S, et al. Valganciclovir prevents cytomegalovirus reactivation in patients receiving alemtuzumab-based therapy. Blood. 2008 Feb 15;111(4):1816-9.

缬更昔洛韦物理化学性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 629.1±65.0 °C at 760 mmHg
• 分子式: C₁₄H₂₂N₆O₅
• 分子量: 354.362
• 闪点: 334.3±34.3 °C
• 精确质量: 354.165161
• PSA: 171.37000
• LogP: -1.28
• InChIKey: WPVFJKSGQUFQAP-UHFFFAOYSA-N
• SMILES: CC(C)C(N)C(=O)OCC(CO)OCn1cnc2c(=O)[nH]c(N)nc21
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.678
• 储存条件: 室温，干燥

缬更昔洛韦安全信息

• 海关编码: 2933990090

缬更昔洛韦海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

缬更昔洛韦靶点实验

查看更多实验

实验名称：Compound was evaluated for inhibition of rat Gabra1 in an in vitro assay with cellula... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-1 External Id：CHEMBL5291801

实验名称：Binding affinity towards rat Gabra1 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：Gamma-aminobutyric acid receptor subunit alpha-1 External Id：CHEMBL5291798

实验名称：Binding affinity towards human ESR1 in an in vitro cell free assay (NIBR assay) measu... 来源：ChEMBL 靶标：Estrogen receptor External Id：CHEMBL5291791

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Binding affinity towards human DRD2 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：D(2) dopamine receptor External Id：CHEMBL5291781

实验名称：Agonist activity at human DRD1 in an in vitro cell-based assay measured by time-resol... 来源：ChEMBL 靶标：D(1A) dopamine receptor External Id：CHEMBL5291777

实验名称：Binding affinity towards human CNR1 in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：Cannabinoid receptor 1 External Id：CHEMBL5291773

实验名称：Binding affinity towards human MC4R in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：Melanocortin receptor 4 External Id：CHEMBL5291832

实验名称：Binding affinity towards human MC3R in an in vitro assay with cellular components mea... 来源：ChEMBL 靶标：Melanocortin receptor 3 External Id：CHEMBL5291831

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缬更昔洛韦英文别名

• L-Valine 2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl Ester
• 2-((2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy)-3-hydroxypropyl L-Valinate
• Valcyte
• Cymeval
• valganciclovir
• 2-[(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methoxy]-3-hydroxypropyl L-valinate
• L-Valine, 2-[(2-amino-3,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]-3-hydroxypropyl ester
• valgancyclovir