Tecalcet Hydrochloride

• 常用名: Tecalcet Hydrochloride
• 英文名: R 568 hydrochloride
• CAS号: 177172-49-5
• 分子量: 340.28700
• 密度: N/A
• 沸点: 416.3ºC at 760 mmHg
• 分子式: C₁₈H₂₃Cl₂NO
• 熔点: N/A
• 闪点: 205.6ºC

Tecalcet Hydrochloride用途

Tecalcet Hydrochloride (R 568 Hydrochloride) 是一个口服有效的拟钙剂,变构正调控钙敏感受体 (CaSR)。Tecalcet Hydrochloride (R 568 Hydrochloride) 可提高激活细胞外Ca2+的敏感性。

Tecalcet Hydrochloride名称

• 中文名: 2-氯-N-[(1R)-1-(3-甲氧基苯基)乙基]苯丙胺盐酸盐
• 英文名: 3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine,hydrochloride

Tecalcet Hydrochloride生物活性

• 描述: Tecalcet Hydrochloride (R 568 Hydrochloride) 是一个口服有效的拟钙剂,变构正调控钙敏感受体 (CaSR)。Tecalcet Hydrochloride (R 568 Hydrochloride) 可提高激活细胞外Ca2+的敏感性。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> CaSR的
• 参考文献:

  [1]. Wada, M., et al. The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. Control of parathyroid cell growth via a calcium receptor. Journal of Clinical Investigation 100(12), 2977-2983 (1997).

  [2]. Nemeth, E.F., et al. The parathyroid calcium receptor: a novel therapeutic target for treating hyperparathyroidism. Pediatr.Nephrol. 10(3), 275-279 (1996).

  [3]. Nemeth, E.F., et al. Calcimimetics with potent and selective activity on the parathyroid calcium receptor. Proceedings of the National Academy of Sciences of the United States of America 95(7), 4040-4045 (1998).

Tecalcet Hydrochloride物理化学性质

• 沸点: 416.3ºC at 760 mmHg
• 分子式: C₁₈H₂₃Cl₂NO
• 分子量: 340.28700
• 闪点: 205.6ºC
• 精确质量: 339.11600
• PSA: 21.26000
• LogP: 5.82490
• InChIKey: YJXUXANREVNZLH-PFEQFJNWSA-N
• SMILES: COc1cccc(C(C)NCCCc2ccccc2Cl)c1.Cl
• 蒸汽压: 3.86E-07mmHg at 25°C
• 储存条件: 2-8°C，密封，干燥

Tecalcet Hydrochloride靶点实验

查看更多实验

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：Thermal Shift Assay. Domain: start/stop: M1-K294 来源：ChEMBL 靶标：Casein kinase I isoform delta External Id：CHEMBL5063814

实验名称：Thermal Shift Assay. Domain: start/stop: M26-R383 来源：ChEMBL 靶标：Glycogen synthase kinase-3 beta External Id：CHEMBL5065589

实验名称：Thermal Shift Assay. Domain: start/stop: S229-K512 来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1 External Id：CHEMBL5060015

实验名称：PDSP Secondary Binding target: ADRA2B - Compounds are tested at 10 uM concentration, ... 来源：ChEMBL 靶标：Alpha-2B adrenergic receptor External Id：CHEMBL5442195

实验名称：GPCR beta-arrestin recruitment assay with target: FPR2 Assay Type: PRESTO-Tango Conce... 来源：ChEMBL 靶标：N-formyl peptide receptor 2 External Id：CHEMBL5209827

实验名称：GPCR beta-arrestin recruitment assay with target: FPR2 Assay Type: PRESTO-Tango Conce... 来源：ChEMBL 靶标：N-formyl peptide receptor 2 External Id：CHEMBL5209826

实验名称：GPCR beta-arrestin recruitment assay with target: GLP1R Assay Type: PRESTO-Tango Conc... 来源：ChEMBL 靶标：Glucagon-like peptide 1 receptor External Id：CHEMBL5209829

实验名称：PDSP Secondary Binding target: HTR2B - Compounds are tested at 10 uM concentration, p... 来源：ChEMBL 靶标：5-hydroxytryptamine receptor 2B External Id：CHEMBL5442192

实验名称：GPCR beta-arrestin recruitment assay with target: FPR2 Assay Type: PRESTO-Tango Conce... 来源：ChEMBL 靶标：N-formyl peptide receptor 2 External Id：CHEMBL5209828

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Tecalcet Hydrochloride英文别名

• Norcalcin
• R-568
• Tecalcet hydrochloride
• KRN-568
• NPS R-568
• Tecalcet HCl