C-DIM12

• 常用名: C-DIM12
• 英文名: C-DIM 12
• CAS号: 178946-89-9
• 分子量: 356.85
• 密度: 1.3±0.1 g/cm3
• 沸点: 585.6±45.0 °C at 760 mmHg
• 分子式: C₂₃H₁₇ClN₂
• 熔点: N/A
• 闪点: 336.1±14.3 °C

C-DIM12用途

C-DIM12是一种人工合成的Nurr1激活剂, 诱导Nurr1和DA基因表达。

C-DIM12名称

• 中文名: C-DIM12
• 英文名: 3,3'-[(4-chlorophenyl)methylene]bis-1H-Indole

C-DIM12生物活性

• 描述: C-DIM12是一种人工合成的Nurr1激活剂, 诱导Nurr1和DA基因表达。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. De Miranda BR, et al. The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB. Mol Pharmacol. 2015 Jun;87(6):1021-34. doi: 10.1124/mol.114.095398. Epub

  [2]. Hammond SL, et al. A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. Neurosci Lett. 2015 Oct 21;607:83-9.

C-DIM12物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 585.6±45.0 °C at 760 mmHg
• 分子式: C₂₃H₁₇ClN₂
• 分子量: 356.85
• 闪点: 336.1±14.3 °C
• LogP: 6.13
• InChIKey: LTLRXTDMXOFBDW-UHFFFAOYSA-N
• SMILES: Clc1ccc(C(c2c[nH]c3ccccc23)c2c[nH]c3ccccc23)cc1
• 外观性状: white solid
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.747
• 储存条件: -20℃

C-DIM12安全信息

• 危险品运输编码: NONH for all modes of transport

C-DIM12靶点实验

查看更多实验

实验名称：Cytotoxicity in rat PC-12 cells assessed as reduction in cell viability at 12.5 to 50... 来源：ChEMBL 靶标：PC-12 External Id：CHEMBL5030650

实验名称：Cytotoxicity in human SKNBE2 cells assessed as reduction in cell viability at 12.5 to... 来源：ChEMBL 靶标：SK-N-BE(2) External Id：CHEMBL5030649

实验名称：Antifungal activity against Cryptococcus neoformans ATCC 90113 by CLSI method 来源：ChEMBL 靶标：Cryptococcus neoformans External Id：CHEMBL2379427

实验名称：Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL2379639

实验名称：Antagonist activity at human FFAR4 expressed in CHO cells assessed as inhibition of T... 来源：ChEMBL 靶标：Free fatty acid receptor 4 External Id：CHEMBL4015239

实验名称：Antibacterial activity against Mycobacterium intracellulare ATCC 23068 by alamar blue... 来源：ChEMBL 靶标：Mycobacterium intracellulare External Id：CHEMBL2379431

实验名称：Agonist activity at Gq protein coupled human FFAR1 expressed in human 1321N1 cells as... 来源：ChEMBL 靶标：Free fatty acid receptor 1 External Id：CHEMBL4015236

实验名称：Antifungal activity against Aspergillus fumigatus ATCC 204305 by CLSI method 来源：ChEMBL 靶标：Aspergillus fumigatus External Id：CHEMBL2379430

实验名称：Agonist activity at human FFAR4 expressed in CHO cells assessed as beta-arrestin recr... 来源：ChEMBL 靶标：Free fatty acid receptor 4 External Id：CHEMBL4015237

实验名称：Antifungal activity against Candida albicans ATCC 90028 by CLSI method 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL2379429

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C-DIM12英文别名

• 3,3'-[(4-Chlorophenyl)methylene]bis(1H-indole)
• C-DIM12