C-DIM 12
Modify Date: 2024-01-02 03:33:15
C-DIM 12 structure
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Common Name | C-DIM 12 | ||
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| CAS Number | 178946-89-9 | Molecular Weight | 356.85 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 585.6±45.0 °C at 760 mmHg | |
| Molecular Formula | C23H17ClN2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 336.1±14.3 °C | |
Use of C-DIM 12C-DIM12 is a synthetic Nurr1 activaor induces Nurr1 and DA gene expression in cell lines and primary neurons.Target: Nurr1in vitro: C-DIM12 as a modulator of Nurr1 activity that results in inhibition of NF-κB-dependent gene expression in glial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters. C-DIM12 Decreases Inflammatory Gene Expression in BV-2 Microglia. C-DIM12 Decreases Expression of NF-κB-Enhanced GFP Expression in Human Embryonic Kidney 293 Reporter Cells.[1] C-DIM12 increases protein levels of exogenously expressed human Nurr1 in transfected neurons.C-DIM12 protects neurons from 6-hydroxydopamine toxicity. [2] |
| Name | 3,3'-[(4-chlorophenyl)methylene]bis-1H-Indole |
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| Synonym | More Synonyms |
| Description | C-DIM12 is a synthetic Nurr1 activaor induces Nurr1 and DA gene expression in cell lines and primary neurons.Target: Nurr1in vitro: C-DIM12 as a modulator of Nurr1 activity that results in inhibition of NF-κB-dependent gene expression in glial cells by stabilizing nuclear corepressor proteins, which reduces binding of p65 to inflammatory gene promoters. C-DIM12 Decreases Inflammatory Gene Expression in BV-2 Microglia. C-DIM12 Decreases Expression of NF-κB-Enhanced GFP Expression in Human Embryonic Kidney 293 Reporter Cells.[1] C-DIM12 increases protein levels of exogenously expressed human Nurr1 in transfected neurons.C-DIM12 protects neurons from 6-hydroxydopamine toxicity. [2] |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 585.6±45.0 °C at 760 mmHg |
| Molecular Formula | C23H17ClN2 |
| Molecular Weight | 356.85 |
| Flash Point | 336.1±14.3 °C |
| LogP | 6.13 |
| Appearance of Characters | white solid |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.747 |
| Storage condition | -20℃ |
| RIDADR | NONH for all modes of transport |
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| 3,3'-[(4-Chlorophenyl)methylene]bis(1H-indole) |
| 1H-Indole, 3,3'-[(4-chlorophenyl)methylene]bis- |
| C-DIM12 |