BAY-876

• 常用名: BAY-876
• 英文名: BAY 876
• CAS号: 1799753-84-6
• 分子量: 496.417
• 密度: 1.5±0.1 g/cm3
• 沸点: 632.3±55.0 °C at 760 mmHg
• 分子式: C₂₄H₁₆F₄N₆O₂
• 熔点: N/A
• 闪点: 336.2±31.5 °C

BAY-876用途

BAY-876是IC50为0.002 uM高选择性的GLUT1抑制剂,在体外有很好的代谢能力,在体内有高的生物利用率。

BAY-876名称

• 中文名: BAY-876
• 英文名: N4-[1-(4-Cyanobenzyl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide

BAY-876生物活性

• 描述: BAY-876是IC50为0.002 uM高选择性的GLUT1抑制剂,在体外有很好的代谢能力,在体内有高的生物利用率。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 癌症
• 参考文献:

  [1]. Siebeneicher H et al. Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876. ChemMedChem. 2016 Aug 23.

BAY-876物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 632.3±55.0 °C at 760 mmHg
• 分子式: C₂₄H₁₆F₄N₆O₂
• 分子量: 496.417
• 闪点: 336.2±31.5 °C
• 精确质量: 496.127075
• LogP: 3.89
• InChIKey: BKLJDIJJOOQUFG-UHFFFAOYSA-N
• SMILES: Cc1c(NC(=O)c2cc(C(N)=O)nc3cc(F)ccc23)c(C(F)(F)F)nn1Cc1ccc(C#N)cc1
• 外观性状: 粉末
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.649
• 储存条件: -20℃

BAY-876靶点实验

查看更多实验

实验名称：Inhibition of human GLUT1 expressed in human DLD-1 cells assessed as reduction in glu... 来源：ChEMBL 靶标：Solute carrier family 2, facilitated glucose transporter member 1 External Id：CHEMBL5658131

实验名称：Inhibition of human GLUT2 expressed in CHO cells assessed as reduction in fructose up... 来源：ChEMBL 靶标：Solute carrier family 2, facilitated glucose transporter member 2 External Id：CHEMBL5658132

实验名称：Thermal Shift Assay. Domain: start/stop: M1-L298 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL5062802

实验名称：Inhibition of human GLUT3 expressed in human GLUT1-/- DLD-1 cells assessed as reducti... 来源：ChEMBL 靶标：Solute carrier family 2, facilitated glucose transporter member 3 External Id：CHEMBL5658133

实验名称：Inhibition of human GLUT4 expressed in CHO cells assessed as reduction in glucose upt... 来源：ChEMBL 靶标：Solute carrier family 2, facilitated glucose transporter member 4 External Id：CHEMBL5658134

实验名称：Clearance in rat hepatocytes 来源：ChEMBL 靶标：N/A External Id：CHEMBL5658135

实验名称：Stability in rat hepatocytes assessed as maximum bioavailability 来源：ChEMBL 靶标：N/A External Id：CHEMBL5658136

实验名称：Selectivity ratio of IC50 for human GLUT4 expressed in CHO cells to IC50 for human GL... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5658137

实验名称：Selectivity ratio of IC50 for human GLUT3 expressed in human GLUT1-/- DLD-1 cells to ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5658138

实验名称：Clearance in human liver microsomes 来源：ChEMBL 靶标：N/A External Id：CHEMBL5658139

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BAY-876英文别名

• N-[1-(4-Cyanobenzyl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide
• BAY-876