JAK3-IN-1

• 常用名: JAK3-IN-1
• 英文名: JAK3-IN-1
• CAS号: 1805787-93-2
• 分子量: 508.015
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₆H₃₀ClN₇O₂
• 熔点: N/A
• 闪点: N/A

JAK3-IN-1用途

JAK3-IN-1是一种有效的JAK3抑制剂, IC50值为4.8 nM, 也能抑制JAK1 (IC50 =896nM) 和JAK2 (IC50 =1050nM)。

JAK3-IN-1名称

• 中文名: JAK3-IN-1
• 英文名: JAK3-IN-1

JAK3-IN-1生物活性

• 描述: JAK3-IN-1是一种有效的JAK3抑制剂, IC50值为4.8 nM, 也能抑制JAK1 (IC50 =896nM) 和JAK2 (IC50 =1050nM)。
• 相关类别:
  研究领域 >> 癌症
• 靶点实验:

  JAK3:4.8 nM (IC50)

  JAK1:896 nM (IC50)

  JAK2:1050 nM (IC50)

  TTK:49 nM (IC50)

  BTK:794 nM (IC50)

  ITK:1070 nM (IC50)

• 参考文献:

  [1]. Tan L, et al. Development of Selective Covalent Janus Kinase 3 Inhibitors. J Med Chem. 2015 Aug 27;58(16):6589-6606.

JAK3-IN-1物理化学性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₂₆H₃₀ClN₇O₂
• 分子量: 508.015
• 精确质量: 507.214966
• LogP: 2.18
• InChIKey: UGXCBYVBIJACEK-UHFFFAOYSA-N
• SMILES: C=CC(=O)Nc1cccc(CNc2nc(Nc3ccc(N4CCN(C)CC4)cc3OC)ncc2Cl)c1
• 折射率: 1.672
• 储存条件: 2-8℃

JAK3-IN-1靶点实验

查看更多实验

实验名称：Irreversible inhibition of recombinant JAK3 kinase domain (unknown origin) assessed a... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK3 External Id：CHEMBL3602077

实验名称：Inhibition of JAK3 in mouse BMDM assessed as inhibition of IL-4 induced STAT6 phospho... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK3 External Id：CHEMBL3602078

实验名称：Inhibition of JAK3 (unknown origin) expressed in mouse BA/F3 cells at 1 uM preincubat... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK3 External Id：CHEMBL3602075

实验名称：Inhibition of TYK2 in mouse BMDM assessed as inhibition of IL-10-induced STAT3 phosph... 来源：ChEMBL 靶标：Non-receptor tyrosine-protein kinase TYK2 External Id：CHEMBL3602081

实验名称：Inhibition of JAK1 in mouse BMDM assessed as inhibition of IFNbeta-induced STAT1 phos... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK1 External Id：CHEMBL3602079

实验名称：Inhibition of JAK2 in mouse BMDM assessed as inhibition of GM-CSF-induced STAT5 phosp... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK2 External Id：CHEMBL3602080

实验名称：Inhibition of JAK2 in human OCL-AML5 cells assessed as inhibition of GM-CSF induced S... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK2 External Id：CHEMBL3602085

实验名称：Inhibition of JAK3 in human TALL-1 cells assessed as inhibition of IL-2 induced STAT5... 来源：ChEMBL 靶标：Tyrosine-protein kinase JAK3 External Id：CHEMBL3602083

实验名称：Plasma clearance in Swiss albino mouse at 2 mg/kg, iv 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3602089

实验名称：Volume of distribution at steady state in Swiss albino mouse at 2 mg/kg, iv 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3602090

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JAK3-IN-1英文别名

• N-(3-{[(5-Chloro-2-{[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]amino}-4-pyrimidinyl)amino]methyl}phenyl)acrylamide
• N-(3-{[(5-Chloro-2-{[2-Methoxy-4-(4-Methylpiperazin-1-Yl)phenyl]amino}pyrimidin-4-Yl)amino]methyl}phenyl)prop-2-Enamide