ND-336

• 常用名: ND-336
• 英文名: ND-336
• CAS号: 1807453-83-3
• 分子量: 371.902
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₇NO₃S₂•HCl
• 熔点: N/A
• 闪点: N/A

ND-336用途

明胶酶MMP2和MMP9和MMP13的选择性抑制剂,Ki分别为85,150和120 nM；对其他MMP的影响最小；通过降低炎症和增强伤口的血管生成和再上皮化来加速糖尿病伤口愈合,从而逆转病理状况。

ND-336名称

• 英文名: 1-(4-{4-[(2-Thiiranylmethyl)sulfonyl]phenoxy}phenyl)methanamine hydrochloride (1:1)

ND-336生物活性

• 描述: 明胶酶MMP2和MMP9和MMP13的选择性抑制剂,Ki分别为85,150和120 nM；对其他MMP的影响最小；通过降低炎症和增强伤口的血管生成和再上皮化来加速糖尿病伤口愈合,从而逆转病理状况。
• 参考文献: References 1. Gao M, et al. Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15226-31. View Related Products by Target Matrix Metalloproteinase (MMP)

ND-336物理化学性质

• 分子式: C₁₆H₁₇NO₃S₂•HCl
• 分子量: 371.902
• 精确质量: 371.041656
• InChIKey: DRGIZFGSEKSFIC-UHFFFAOYSA-N
• SMILES: Cl.NCc1ccc(Oc2ccc(S(=O)(=O)CC3CS3)cc2)cc1
• 储存条件: 2-8°C

ND-336靶点实验

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实验名称：Inhibition of MMP8 activity in db/db BKS.Cg-Dock7m+/+ Lepr db/J mouse model of full-t... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4201815

实验名称：Inhibition of MMP9 activity in db/db BKS.Cg-Dock7m+/+ Lepr db/J mouse model of full-t... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4201814

实验名称：Inhibition of human recombinant MMP7 at 100 uM using MOCAc-Pro-Leu-Gly-Leu-A2pr(Dnp)-... 来源：ChEMBL 靶标：Matrilysin External Id：CHEMBL4201801

实验名称：Inhibition of human recombinant MMP3 catalytic domain at 100 uM using MOCAc-Arg-Pro-L... 来源：ChEMBL 靶标：Stromelysin-1 External Id：CHEMBL4201800

实验名称：Induction of wound healing in db/db BKS.Cg-Dock7m+/+ Lepr db/J mouse model of full-th... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4201813

实验名称：Inhibition of human recombinant MMP1 catalytic domain at 100 uM using Mca-Lys-Pro-Leu... 来源：ChEMBL 靶标：Interstitial collagenase External Id：CHEMBL4201797

实验名称：Induction of wound healing in db/db BKS.Cg-Dock7m+/+ Lepr db/J mouse model of full-th... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL4201812

实验名称：Selectivity index, ratio of Ki for non-competitive inhibition of human recombinant MM... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4201807

实验名称：Inhibition of human recombinant ADAM10 at 100 uM using Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Al... 来源：ChEMBL 靶标：Disintegrin and metalloproteinase domain-containing protein 10 External Id：CHEMBL4201806

实验名称：Inhibition of human recombinant ADAM9 at 100 uM using Mca-Pro-Leu-Ala-Gln-Ala-Val-Dpa... 来源：ChEMBL 靶标：Disintegrin and metalloproteinase domain-containing protein 9 External Id：CHEMBL4201805

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ND-336英文别名

• 1-(4-{4-[(2-Thiiranylmethyl)sulfonyl]phenoxy}phenyl)methanamine hydrochloride (1:1)
• Benzenemethanamine, 4-[4-[(thiiranylmethyl)sulfonyl]phenoxy]-, hydrochloride (1:1)