8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one

• 常用名: 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one
• 英文名: 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one
• CAS号: 1810721-14-2
• 分子量: 422.9
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₃ClN₆O
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 8-[3-Chloro-5-[4-(1-methylpyrazol-4-yl)phenyl]pyridin-4-yl]-1,3,8-triazaspiro[4.5]decan-4-one

物理化学性质

• 分子式: C₂₂H₂₃ClN₆O
• 分子量: 422.9
• InChIKey: ZLJBWVWHTDCWFO-UHFFFAOYSA-N
• SMILES: Cn1cc(-c2ccc(-c3cncc(Cl)c3N3CCC4(CC3)NCNC4=O)cc2)cn1

靶点实验

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实验名称：Permeability across apical to basolateral side in human Caco2 cells after 2 hrs by LC... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3803423

实验名称：Intrinsic clearance in mouse microsomes preincubated for 5 mins followed by addition ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3803439

实验名称：Intrinsic clearance in rat microsomes preincubated for 5 mins followed by addition of... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3803438

实验名称：Efflux ratio in human Caco2 cells after 2 hrs by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL3803422

实验名称：Binding affinity to CDK8/CDK19 in human 7dF3 cells preincubated for 2 hrs followed by... 来源：ChEMBL 靶标：Cyclin-dependent kinase 19 External Id：CHEMBL3803421

实验名称：Binding affinity to human CDK19 (1 to 502 amino acid residues)/Cyclin C (1 to 283 ami... 来源：ChEMBL 靶标：Cyclin-C External Id：CHEMBL3803437

实验名称：Binding affinity to His-tagged CDK8 (unknown origin) after 60 mins by FRET based lant... 来源：ChEMBL 靶标：Cyclin-dependent kinase 8 External Id：CHEMBL3803436

实验名称：Thermodynamic solubility of compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL3803442

实验名称：Kinetic solubility of compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL3803441

实验名称：Intrinsic clearance in human microsomes preincubated for 5 mins followed by addition ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3803440

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